SEZ6

Entrez Summary: The protein encoded by this gene is thought to contain five cysteine-rich motifs that are similar to sushi domains, as well as two domains similar to the amino terminal half of the CUB (for complement C1r/C1s, Uegf, Bmp1) domain. Mutations in this gene have been associated with febrile seizures. [provided by RefSeq, Jul 2016].
UniProt Summary: May play a role in cell-cell recognition and in neuronal membrane signaling. Seems to be important for the achievement of the necessary balance between dendrite elongation and branching during the elaboration of a complex dendritic arbor. Involved in the development of appropriate excitatory synaptic connectivity (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

CUB
Sushi

synapse maturation
regulation of protein kinase C signaling
apical dendrite
cerebellar Purkinje cell layer development
dendritic shaft
cerebellar cortex development
excitatory postsynaptic potential
chemical synaptic transmission, postsynaptic
adult locomotory behavior
regulation of postsynaptic membrane potential
cerebellum development
metencephalon development
adult behavior
dendritic spine
regulation of dendrite development
hindbrain development
locomotory behavior
developmental maturation
synapse organization
neuronal cell body
chemical synaptic transmission
anterograde trans-synaptic signaling
cell surface receptor signaling pathway involved in cell-cell signaling
regulation of membrane potential
trans-synaptic signaling
synaptic signaling
regulation of neuron projection development
behavior
regulation of neuron differentiation
regulation of plasma membrane bounded cell projection organization
perinuclear region of cytoplasm
regulation of cell projection organization
brain development
head development
regulation of neurogenesis
regulation of nervous system development
regulation of cell development
central nervous system development
endoplasmic reticulum
cell-cell signaling