SFRP5 [The Human Chemical-Genetic Interaction Map Project]

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======= SFRP5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SFRP5
  * **<color #00a2e8>Official Name</color>**: secreted frizzled related protein 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6425|6425]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5T4F7|Q5T4F7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SFRP5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SFRP5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604158|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP5 may be involved in determining the polarity of photoreceptor, and perhaps, other cells in the retina.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NTR|
|Fz|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of Wnt signaling pathway involved in digestive tract morphogenesis|
|regulation of Wnt signaling pathway involved in digestive tract morphogenesis|
|Wnt-protein binding|
|negative regulation of protein kinase B signaling|
|regulation of BMP signaling pathway|
|canonical Wnt signaling pathway|
|non-canonical Wnt signaling pathway|
|negative regulation of DNA-binding transcription factor activity|
|negative regulation of canonical Wnt signaling pathway|
|establishment or maintenance of cell polarity|
|negative regulation of Wnt signaling pathway|
|regulation of protein kinase B signaling|
|visual perception|
|sensory perception of light stimulus|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of cellular response to growth factor stimulus|
|regulation of canonical Wnt signaling pathway|
|cell-cell signaling by wnt|
|Wnt signaling pathway|
|regulation of Wnt signaling pathway|
|regulation of DNA-binding transcription factor activity|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|negative regulation of intracellular signal transduction|
|negative regulation of cell population proliferation|
|apoptotic process|
|negative regulation of developmental process|
|sensory perception|
|programmed cell death|
|regulation of anatomical structure morphogenesis|
|cell death|
|cell-cell signaling|
|negative regulation of molecular function|
|negative regulation of multicellular organismal process|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|nervous system process|
|extracellular space|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|regulation of intracellular signal transduction|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp332|Adefovir 20μM R07 exp332]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11862
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SFRP5 Expression in NALM6 Cells: -1.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>