SFRP5

Gene Information

Official Symbol: SFRP5
Official Name: secreted frizzled related protein 5
Aliases and Previous Symbols: N/A
Entrez ID: 6425
UniProt: Q5T4F7
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP5 may be involved in determining the polarity of photoreceptor, and perhaps, other cells in the retina.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 11862
Expression level (log2 read counts): -1.52

Expression Distribution

NTR
Fz

negative regulation of Wnt signaling pathway involved in digestive tract morphogenesis
regulation of Wnt signaling pathway involved in digestive tract morphogenesis
Wnt-protein binding
negative regulation of protein kinase B signaling
regulation of BMP signaling pathway
canonical Wnt signaling pathway
non-canonical Wnt signaling pathway
negative regulation of DNA-binding transcription factor activity
negative regulation of canonical Wnt signaling pathway
establishment or maintenance of cell polarity
negative regulation of Wnt signaling pathway
regulation of protein kinase B signaling
visual perception
sensory perception of light stimulus
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
regulation of cellular response to growth factor stimulus
regulation of canonical Wnt signaling pathway
cell-cell signaling by wnt
Wnt signaling pathway
regulation of Wnt signaling pathway
regulation of DNA-binding transcription factor activity
cell surface receptor signaling pathway involved in cell-cell signaling
negative regulation of intracellular signal transduction
negative regulation of cell population proliferation
apoptotic process
negative regulation of developmental process
sensory perception
programmed cell death
regulation of anatomical structure morphogenesis
cell death
cell-cell signaling
negative regulation of molecular function
negative regulation of multicellular organismal process
negative regulation of signal transduction
negative regulation of cell communication
negative regulation of signaling
nervous system process
extracellular space
regulation of cell population proliferation
negative regulation of response to stimulus