SFTPA1

Entrez Summary: This gene encodes a lung surfactant protein that is a member of a subfamily of C-type lectins called collectins. The encoded protein binds specific carbohydrate moieties found on lipids and on the surface of microorganisms. This protein plays an essential role in surfactant homeostasis and in the defense against respiratory pathogens. Mutations in this gene are associated with idiopathic pulmonary fibrosis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Collagen
Lectin C

lamellar body
opsonization
surfactant homeostasis
chemical homeostasis within a tissue
monosaccharide binding
clathrin-coated endocytic vesicle
lipid transporter activity
multivesicular body
lipopolysaccharide binding
respiratory gaseous exchange by respiratory system
rough endoplasmic reticulum
collagen trimer
positive regulation of phagocytosis
regulation of phagocytosis
toll-like receptor signaling pathway
pattern recognition receptor signaling pathway
tissue homeostasis
innate immune response-activating signal transduction
activation of innate immune response
lipid transport
lipid localization
multicellular organismal homeostasis
phagocytosis
anatomical structure homeostasis
positive regulation of innate immune response
positive regulation of response to biotic stimulus
regulation of innate immune response
positive regulation of defense response
positive regulation of multi-organism process
regulation of response to biotic stimulus
regulation of vesicle-mediated transport
immune response-activating signal transduction
immune response-regulating signaling pathway
positive regulation of response to external stimulus
activation of immune response
regulation of defense response
regulation of multi-organism process
positive regulation of immune response
endoplasmic reticulum membrane
positive regulation of transport