SGCB

Entrez Summary: This gene encodes a member of the sarcoglycan family. Sarcoglycans are transmembrane components in the dystrophin-glycoprotein complex which help stabilize the muscle fiber membranes and link the muscle cytoskeleton to the extracellular matrix. Mutations in this gene have been associated with limb-girdle muscular dystrophy.[provided by RefSeq, Oct 2008].
UniProt Summary: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

sarcoglycan complex
vascular smooth muscle cell development
vascular smooth muscle cell differentiation
dystrophin-associated glycoprotein complex
smooth muscle cell differentiation
muscle fiber development
cardiac muscle cell development
cardiac cell development
cardiac muscle cell differentiation
sarcolemma
cardiocyte differentiation
striated muscle cell development
muscle cell development
cardiac muscle tissue development
striated muscle cell differentiation
muscle cell differentiation
striated muscle tissue development
muscle organ development
muscle tissue development
cytoskeleton
muscle structure development
vasculature development
cardiovascular system development
heart development
circulatory system development
integral component of plasma membrane
cell development
tissue development