SGPL1 [The Human Chemical-Genetic Interaction Map Project]

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======= SGPL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SGPL1
  * **<color #00a2e8>Official Name</color>**: sphingosine-1-phosphate lyase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8879|8879]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95470|O95470]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SGPL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SGPL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603729|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis. {ECO:0000269|PubMed:11018465, ECO:0000269|PubMed:14570870, ECO:0000269|PubMed:24809814, ECO:0000269|PubMed:28165339}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Aminotran 1 2|
|Pyridoxal deC|
|Aminotran 5|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|sphinganine-1-phosphate aldolase activity|
|carboxy-lyase activity|
|luteinization|
|fibroblast migration|
|Leydig cell differentiation|
|androgen metabolic process|
|sphingolipid catabolic process|
|face morphogenesis|
|estrogen metabolic process|
|platelet-derived growth factor receptor signaling pathway|
|membrane lipid catabolic process|
|head morphogenesis|
|ovulation cycle process|
|body morphogenesis|
|face development|
|pyridoxal phosphate binding|
|regulation of multicellular organism growth|
|ovulation cycle|
|vasculogenesis|
|ceramide metabolic process|
|female gonad development|
|post-embryonic development|
|roof of mouth development|
|sphingolipid biosynthetic process|
|development of primary female sexual characteristics|
|integral component of endoplasmic reticulum membrane|
|female sex differentiation|
|cellular hormone metabolic process|
|membrane lipid biosynthetic process|
|male gonad development|
|development of primary male sexual characteristics|
|sphingolipid metabolic process|
|male sex differentiation|
|ameboidal-type cell migration|
|cellular lipid catabolic process|
|hormone metabolic process|
|membrane lipid metabolic process|
|gonad development|
|development of primary sexual characteristics|
|skeletal system morphogenesis|
|steroid metabolic process|
|sex differentiation|
|kidney development|
|rhythmic process|
|apoptotic signaling pathway|
|renal system development|
|lipid catabolic process|
|urogenital system development|
|fatty acid metabolic process|
|regulation of developmental growth|
|blood vessel morphogenesis|
|reproductive structure development|
|reproductive system development|
|blood vessel development|
|skeletal system development|
|vasculature development|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cardiovascular system development|
|monocarboxylic acid metabolic process|
|regulation of hormone levels|
|spermatogenesis|
|hemopoiesis|
|male gamete generation|
|lipid biosynthetic process|
|hematopoietic or lymphoid organ development|
|immune system development|
|tube morphogenesis|
|developmental process involved in reproduction|
|regulation of growth|
|gamete generation|
|enzyme linked receptor protein signaling pathway|
|head development|
|cellular amide metabolic process|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|tube development|
|circulatory system development|
|carboxylic acid metabolic process|
|apoptotic process|
|endoplasmic reticulum membrane|
|animal organ morphogenesis|
|cellular lipid metabolic process|
|cell migration|
|multi-organism reproductive process|
|oxoacid metabolic process|
|endoplasmic reticulum|
|organic acid metabolic process|
|programmed cell death|
|organonitrogen compound catabolic process|
|localization of cell|
|cell motility|
|cell death|
|lipid metabolic process|
|locomotion|
|organonitrogen compound biosynthetic process|
|reproductive process|
|reproduction|
|movement of cell or subcellular component|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|-5.02|
|[[:results:exp277|Curcumin 6.5μM R06 exp277]]|-1.96|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-1.7|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|1.81|
|[[:results:exp132|Metformin 40μM R03 exp132]]|1.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4115
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SGPL1 Expression in NALM6 Cells: 6.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>