SGPL1

Entrez Summary: N/A
UniProt Summary: Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis. {ECO:0000269|PubMed:11018465, ECO:0000269|PubMed:14570870, ECO:0000269|PubMed:24809814, ECO:0000269|PubMed:28165339}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

sphinganine-1-phosphate aldolase activity
carboxy-lyase activity
luteinization
fibroblast migration
Leydig cell differentiation
androgen metabolic process
sphingolipid catabolic process
face morphogenesis
estrogen metabolic process
platelet-derived growth factor receptor signaling pathway
membrane lipid catabolic process
head morphogenesis
ovulation cycle process
body morphogenesis
face development
pyridoxal phosphate binding
regulation of multicellular organism growth
ovulation cycle
vasculogenesis
ceramide metabolic process
female gonad development
post-embryonic development
roof of mouth development
sphingolipid biosynthetic process
development of primary female sexual characteristics
integral component of endoplasmic reticulum membrane
female sex differentiation
cellular hormone metabolic process
membrane lipid biosynthetic process
male gonad development
development of primary male sexual characteristics
sphingolipid metabolic process
male sex differentiation
ameboidal-type cell migration
cellular lipid catabolic process
hormone metabolic process
membrane lipid metabolic process
gonad development
development of primary sexual characteristics
skeletal system morphogenesis