SGPP1

Entrez Summary: N/A
UniProt Summary: Specifically dephosphorylates sphingosine 1-phosphate (S1P), dihydro-S1P, and phyto-S1P. Does not act on ceramide 1- phoshate, lysophosphatidic acid or phosphatidic acid. Regulates the intracellular levels of the bioactive sphingolipid metabolite S1P that regulates diverse biological processes acting both as an extracellular receptor ligand or as an intracellular second messenger (PubMed:12815058, PubMed:11756451). Involved in efficient ceramide synthesis from exogenous sphingoid bases. Converts S1P to sphingosine, which is readily metabolized to ceramide via ceramide synthase. In concert with sphingosine kinase 2 (SphK2), recycles sphingosine into ceramide though a phosphorylation/dephosphorylation cycle. Regulates intracellular ceramide levels, which in turn regulate apoptosis (By similarity). Via S1P levels, modulates resting tone, intracellular Ca(2+) and myogenic vasoconstriction in resistance arteries (PubMed:18583713). Also involved in unfolded protein response (UPR) and ER stress-induced autophagy via regulation of intracellular S1P levels (PubMed:20798685). {ECO:0000250|UniProtKB:Q9JI99, ECO:0000269|PubMed:11756451, ECO:0000269|PubMed:12815058, ECO:0000269|PubMed:18583713, ECO:0000269|PubMed:20798685}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 5/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	1/26
breast	0/33
central nervous system	1/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	2/29
uterus	0/5

Expression Distribution

sphinganine-1-phosphate metabolic process
sphingosine-1-phosphate phosphatase activity
ER to Golgi ceramide transport
sphingosine metabolic process
ceramide transport
sphingoid metabolic process
diol metabolic process
intracellular lipid transport
regulation of keratinocyte differentiation
regulation of epidermal cell differentiation
regulation of epidermis development
sphingolipid biosynthetic process
extrinsic apoptotic signaling pathway
polyol metabolic process
membrane lipid biosynthetic process
regulation of epithelial cell differentiation
intrinsic apoptotic signaling pathway
sphingolipid metabolic process
ammonium ion metabolic process
membrane lipid metabolic process
apoptotic signaling pathway
lipid transport
dephosphorylation
alcohol metabolic process
lipid localization
phospholipid metabolic process
organic hydroxy compound metabolic process
lipid biosynthetic process
organophosphate metabolic process
apoptotic process
endoplasmic reticulum membrane
cellular lipid metabolic process
programmed cell death
cell death
lipid metabolic process
organonitrogen compound biosynthetic process
intracellular transport
amide transport
intracellular signal transduction
small molecule metabolic process