SGPP2

Entrez Summary: N/A
UniProt Summary: Has specific phosphohydrolase activity towards sphingoid base 1-phosphates. Has high phosphohydrolase activity against dihydrosphingosine-1-phosphate and sphingosine-1-phosphate (S1P) in vitro. May play a role in attenuating intracellular sphingosine 1-phosphate (S1P) signaling. May play a role in pro-inflammatory signaling. {ECO:0000269|PubMed:12411432, ECO:0000269|PubMed:17113265}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

sphingosine-1-phosphate phosphatase activity
regulation of type B pancreatic cell proliferation
sphingosine metabolic process
sphingoid metabolic process
diol metabolic process
sphingolipid biosynthetic process
polyol metabolic process
membrane lipid biosynthetic process
sphingolipid metabolic process
ammonium ion metabolic process
membrane lipid metabolic process
dephosphorylation
alcohol metabolic process
regulation of epithelial cell proliferation
organic hydroxy compound metabolic process
lipid biosynthetic process
endoplasmic reticulum membrane
cellular lipid metabolic process
endoplasmic reticulum
lipid metabolic process
organonitrogen compound biosynthetic process
regulation of cell population proliferation
small molecule metabolic process