SGTB

Official Symbol: SGTB
Official Name: small glutamine rich tetratricopeptide repeat containing beta
Aliases and Previous Symbols: N/A
Entrez ID: 54557
UniProt: Q96EQ0
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: N/A
UniProt Summary: Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

TPR 2
TPR 1

positive regulation of chaperone-mediated protein folding
TRC complex
positive regulation of protein folding
regulation of chaperone-mediated protein folding
regulation of protein folding
posttranslational protein targeting to endoplasmic reticulum membrane
ubiquitin-dependent ERAD pathway
ERAD pathway
protein targeting to ER
establishment of protein localization to endoplasmic reticulum
protein localization to endoplasmic reticulum
protein targeting to membrane
response to endoplasmic reticulum stress
establishment of protein localization to membrane
proteasome-mediated ubiquitin-dependent protein catabolic process
proteasomal protein catabolic process
protein targeting
establishment of protein localization to organelle
protein localization to membrane
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
protein catabolic process
protein localization to organelle
cellular macromolecule catabolic process
intracellular protein transport
response to organonitrogen compound
macromolecule catabolic process
organonitrogen compound catabolic process
response to nitrogen compound
proteolysis
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization