SH2B2 [The Human Chemical-Genetic Interaction Map Project]

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======= SH2B2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SH2B2
  * **<color #00a2e8>Official Name</color>**: SH2B adaptor protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10603|10603]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14492|O14492]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SH2B2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SH2B2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605300|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt's lymphoma cell lines, it is tyrosine-phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to the Shc/Grb2 pathway. [provided by RefSeq, Jun 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PH|
|Phe ZIP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|B-1 B cell homeostasis|
|transmembrane receptor protein tyrosine kinase adaptor activity|
|B cell homeostasis|
|brown fat cell differentiation|
|SH3/SH2 adaptor activity|
|lymphocyte homeostasis|
|stress fiber|
|leukocyte homeostasis|
|actin filament|
|insulin receptor signaling pathway|
|ruffle|
|fat cell differentiation|
|cellular response to insulin stimulus|
|homeostasis of number of cells|
|response to insulin|
|regulation of Ras protein signal transduction|
|cellular response to peptide hormone stimulus|
|blood coagulation|
|coagulation|
|antigen receptor-mediated signaling pathway|
|hemostasis|
|cellular response to peptide|
|regulation of small GTPase mediated signal transduction|
|response to peptide hormone|
|immune response-activating cell surface receptor signaling pathway|
|response to peptide|
|wound healing|
|immune response-regulating cell surface receptor signaling pathway|
|actin cytoskeleton organization|
|regulation of body fluid levels|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|immune response-activating signal transduction|
|actin filament-based process|
|response to wounding|
|immune response-regulating signaling pathway|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|activation of immune response|
|cellular response to nitrogen compound|
|cytokine-mediated signaling pathway|
|enzyme linked receptor protein signaling pathway|
|positive regulation of immune response|
|response to hormone|
|response to organonitrogen compound|
|cellular response to cytokine stimulus|
|cellular response to oxygen-containing compound|
|identical protein binding|
|response to nitrogen compound|
|response to cytokine|
|cytoskeleton organization|
|regulation of immune response|
|positive regulation of immune system process|
|cellular response to endogenous stimulus|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|intracellular signal transduction|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14768
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SH2B2 Expression in NALM6 Cells: 3.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>