SH2B2

Entrez Summary: The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt's lymphoma cell lines, it is tyrosine-phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to the Shc/Grb2 pathway. [provided by RefSeq, Jun 2009].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Expression Distribution

PH
Phe ZIP

B-1 B cell homeostasis
transmembrane receptor protein tyrosine kinase adaptor activity
B cell homeostasis
brown fat cell differentiation
SH3/SH2 adaptor activity
lymphocyte homeostasis
stress fiber
leukocyte homeostasis
actin filament
insulin receptor signaling pathway
ruffle
fat cell differentiation
cellular response to insulin stimulus
homeostasis of number of cells
response to insulin
regulation of Ras protein signal transduction
cellular response to peptide hormone stimulus
blood coagulation
coagulation
antigen receptor-mediated signaling pathway
hemostasis
cellular response to peptide
regulation of small GTPase mediated signal transduction
response to peptide hormone
immune response-activating cell surface receptor signaling pathway
response to peptide
wound healing
immune response-regulating cell surface receptor signaling pathway
actin cytoskeleton organization
regulation of body fluid levels
transmembrane receptor protein tyrosine kinase signaling pathway
immune response-activating signal transduction
actin filament-based process
response to wounding
immune response-regulating signaling pathway
cellular response to organonitrogen compound
cellular response to hormone stimulus
activation of immune response
cellular response to nitrogen compound
cytokine-mediated signaling pathway