SH3GL2 [The Human Chemical-Genetic Interaction Map Project]

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======= SH3GL2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SH3GL2
  * **<color #00a2e8>Official Name</color>**: SH3 domain containing GRB2 like 2, endophilin A1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6456|6456]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99962|Q99962]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SH3GL2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SH3GL2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604465|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes. {ECO:0000250|UniProtKB:Q62420}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|BAR|
|SH3 1|
|BAR 2|
|SH3 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|vesicle scission|
|membrane bending|
|membrane tubulation|
|lipid tube assembly|
|positive regulation of membrane tubulation|
|synaptic vesicle uncoating|
|regulation of membrane tubulation|
|clathrin coat disassembly|
|photoreceptor ribbon synapse|
|basal dendrite|
|vesicle uncoating|
|cellular response to brain-derived neurotrophic factor stimulus|
|dendrite extension|
|membrane fission|
|presynaptic cytosol|
|regulation of plasma membrane organization|
|regulation of clathrin-dependent endocytosis|
|protein-lipid complex assembly|
|clathrin-coated endocytic vesicle membrane|
|hippocampal mossy fiber to CA3 synapse|
|protein depolymerization|
|synaptic vesicle endocytosis|
|presynaptic endocytosis|
|negative regulation of epidermal growth factor receptor signaling pathway|
|protein-lipid complex subunit organization|
|cellular response to nerve growth factor stimulus|
|negative regulation of ERBB signaling pathway|
|response to nerve growth factor|
|synaptic vesicle recycling|
|regulation of receptor internalization|
|neuron projection extension|
|synaptic vesicle membrane|
|Schaffer collateral - CA1 synapse|
|regulation of epidermal growth factor receptor signaling pathway|
|developmental cell growth|
|cell growth|
|regulation of ERBB signaling pathway|
|antigen processing and presentation of exogenous peptide antigen via MHC class II|
|antigen processing and presentation of peptide antigen via MHC class II|
|regulation of receptor-mediated endocytosis|
|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|
|developmental growth involved in morphogenesis|
|synaptic vesicle cycle|
|vesicle-mediated transport in synapse|
|cellular protein complex disassembly|
|lipid binding|
|antigen processing and presentation of exogenous peptide antigen|
|antigen processing and presentation of exogenous antigen|
|protein C-terminus binding|
|antigen processing and presentation of peptide antigen|
|regulation of endocytosis|
|antigen processing and presentation|
|protein-containing complex disassembly|
|early endosome|
|glutamatergic synapse|
|neuronal cell body|
|developmental growth|
|growth|
|cellular component disassembly|
|protein kinase binding|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cellular response to growth factor stimulus|
|cell part morphogenesis|
|response to growth factor|
|regulation of vesicle-mediated transport|
|endocytosis|
|Golgi membrane|
|neuron projection development|
|import into cell|
|perinuclear region of cytoplasm|
|cell morphogenesis|
|neuron development|
|cellular component morphogenesis|
|cellular protein-containing complex assembly|
|membrane organization|
|protein homodimerization activity|
|central nervous system development|
|neuron differentiation|
|identical protein binding|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|response to endogenous stimulus|
|generation of neurons|
|protein-containing complex assembly|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|establishment of localization in cell|
|protein-containing complex subunit organization|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9819
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SH3GL2 Expression in NALM6 Cells: -4.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>