SH3GL2

Entrez Summary: N/A
UniProt Summary: Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes. {ECO:0000250|UniProtKB:Q62420}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

vesicle scission
membrane bending
membrane tubulation
lipid tube assembly
positive regulation of membrane tubulation
synaptic vesicle uncoating
regulation of membrane tubulation
clathrin coat disassembly
photoreceptor ribbon synapse
basal dendrite
vesicle uncoating
cellular response to brain-derived neurotrophic factor stimulus
dendrite extension
membrane fission
presynaptic cytosol
regulation of plasma membrane organization
regulation of clathrin-dependent endocytosis
protein-lipid complex assembly
clathrin-coated endocytic vesicle membrane
hippocampal mossy fiber to CA3 synapse
protein depolymerization
synaptic vesicle endocytosis
presynaptic endocytosis
negative regulation of epidermal growth factor receptor signaling pathway
protein-lipid complex subunit organization
cellular response to nerve growth factor stimulus
negative regulation of ERBB signaling pathway
response to nerve growth factor
synaptic vesicle recycling
regulation of receptor internalization
neuron projection extension
synaptic vesicle membrane
Schaffer collateral - CA1 synapse
regulation of epidermal growth factor receptor signaling pathway
developmental cell growth
cell growth
regulation of ERBB signaling pathway
antigen processing and presentation of exogenous peptide antigen via MHC class II
antigen processing and presentation of peptide antigen via MHC class II
regulation of receptor-mediated endocytosis