SH3GL3

Entrez Summary: N/A
UniProt Summary: Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
NN-Diethyl-meta-toluamide 100μM R05 exp237	-2.71
LB-100 4.1μM R02 exp72	-2.1
Etoposide 0.1μM R05 exp198	-1.96

negative regulation of clathrin-dependent endocytosis
postsynaptic endosome
regulation of clathrin-dependent endocytosis
postsynaptic density, intracellular component
negative regulation of receptor-mediated endocytosis
negative regulation of endocytosis
acrosomal vesicle
presynapse
regulation of receptor-mediated endocytosis
early endosome membrane
lipid binding
protein C-terminus binding
regulation of endocytosis
glutamatergic synapse
positive regulation of neuron differentiation
positive regulation of neurogenesis
negative regulation of transport
positive regulation of nervous system development
positive regulation of cell development
regulation of vesicle-mediated transport
endocytosis
regulation of neuron differentiation
import into cell
negative regulation of cellular component organization
regulation of neurogenesis
regulation of nervous system development
regulation of cell development
positive regulation of cell differentiation
central nervous system development
identical protein binding
positive regulation of developmental process
generation of neurons
neurogenesis
positive regulation of multicellular organismal process
regulation of cell differentiation
regulation of transport
vesicle-mediated transport