SHANK1 [The Human Chemical-Genetic Interaction Map Project]

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======= SHANK1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SHANK1
  * **<color #00a2e8>Official Name</color>**: SH3 and multiple ankyrin repeat domains 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=50944|50944]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y566|Q9Y566]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SHANK1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SHANK1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604999|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SAM 1|
|PDZ|
|SH3 2|
|SAM 2|
|SH3 1|
|Ank 2|
|Ank|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|somatostatin receptor binding|
|determination of affect|
|sensory processing|
|habituation|
|GKAP/Homer scaffold activity|
|ankyrin repeat binding|
|synaptic growth at neuromuscular junction|
|nonassociative learning|
|neuron spine|
|postsynaptic density assembly|
|righting reflex|
|postsynaptic specialization assembly|
|olfactory behavior|
|cytoskeletal anchoring at plasma membrane|
|NMDA selective glutamate receptor complex|
|synapse maturation|
|ionotropic glutamate receptor complex|
|excitatory synapse assembly|
|postsynaptic density organization|
|chemosensory behavior|
|vocalization behavior|
|postsynaptic specialization organization|
|dendritic spine morphogenesis|
|postsynapse assembly|
|reflex|
|receptor signaling complex adaptor activity|
|negative regulation of actin filament bundle assembly|
|regulation of AMPA receptor activity|
|positive regulation of excitatory postsynaptic potential|
|dendritic spine development|
|excitatory synapse|
|dendritic spine organization|
|long-term memory|
|positive regulation of synaptic transmission, glutamatergic|
|ionotropic glutamate receptor binding|
|brain morphogenesis|
|neuron projection organization|
|modulation of excitatory postsynaptic potential|
|neuromuscular junction development|
|positive regulation of dendritic spine development|
|long-term synaptic potentiation|
|social behavior|
|intraspecies interaction between organisms|
|neuromuscular process controlling balance|
|dendrite morphogenesis|
|scaffold protein binding|
|protein localization to synapse|
|positive regulation of nervous system process|
|regulation of glutamate receptor signaling pathway|
|multi-organism behavior|
|regulation of synaptic transmission, glutamatergic|
|regulation of dendritic spine development|
|positive regulation of dendrite development|
|regulation of neurotransmitter receptor activity|
|maintenance of protein location in cell|
|associative learning|
|Schaffer collateral - CA1 synapse|
|postsynapse organization|
|regulation of actin filament bundle assembly|
|synapse assembly|
|maintenance of location in cell|
|dendrite development|
|maintenance of protein location|
|neuromuscular process|
|memory|
|negative regulation of supramolecular fiber organization|
|SH3 domain binding|
|regulation of nervous system process|
|negative regulation of cytoskeleton organization|
|adult behavior|
|learning|
|dendritic spine|
|regulation of dendrite development|
|positive regulation of synaptic transmission|
|maintenance of location|
|regulation of cation channel activity|
|regulation of signaling receptor activity|
|regulation of synaptic plasticity|
|protein C-terminus binding|
|postsynaptic membrane|
|developmental maturation|
|postsynaptic density|
|regulation of ion transmembrane transporter activity|
|learning or memory|
|regulation of actin filament organization|
|regulation of transmembrane transporter activity|
|protein-containing complex binding|
|synapse organization|
|regulation of transporter activity|
|positive regulation of neuron projection development|
|cognition|
|neuron projection|
|regulation of cation transmembrane transport|
|regulation of actin cytoskeleton organization|
|glutamatergic synapse|
|regulation of supramolecular fiber organization|
|positive regulation of neuron differentiation|
|negative regulation of organelle organization|
|positive regulation of cell projection organization|
|regulation of actin filament-based process|
|developmental growth|
|growth|
|dendrite|
|regulation of membrane potential|
|cell morphogenesis involved in neuron differentiation|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|positive regulation of neurogenesis|
|regulation of ion transmembrane transport|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|regulation of neuron projection development|
|cell part morphogenesis|
|positive regulation of nervous system development|
|regulation of cytoskeleton organization|
|positive regulation of cell development|
|cell junction|
|cell morphogenesis involved in differentiation|
|regulation of transmembrane transport|
|behavior|
|regulation of system process|
|regulation of neuron differentiation|
|neuron projection development|
|regulation of plasma membrane bounded cell projection organization|
|regulation of ion transport|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|cell morphogenesis|
|brain development|
|organelle assembly|
|head development|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|regulation of nervous system development|
|regulation of cell development|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|sensory perception|
|central nervous system development|
|neuron differentiation|
|identical protein binding|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|positive regulation of developmental process|
|nervous system process|
|generation of neurons|
|protein-containing complex assembly|
|cellular protein localization|
|cellular macromolecule localization|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|protein-containing complex subunit organization|
|regulation of transport|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp471|Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471]]|1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18936
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SHANK1 Expression in NALM6 Cells: 5.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>