SHANK1
Gene Information
- Official Symbol: SHANK1
- Official Name: SH3 and multiple ankyrin repeat domains 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 50944
- UniProt: Q9Y566
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction.
Pfam Domains GO Terms
Pfam Domains
| SAM 1 |
| PDZ |
| SH3 2 |
| SAM 2 |
| SH3 1 |
| Ank 2 |
| Ank |
GO Terms
| somatostatin receptor binding |
| determination of affect |
| sensory processing |
| habituation |
| GKAP/Homer scaffold activity |
| ankyrin repeat binding |
| synaptic growth at neuromuscular junction |
| nonassociative learning |
| neuron spine |
| postsynaptic density assembly |
| righting reflex |
| postsynaptic specialization assembly |
| olfactory behavior |
| cytoskeletal anchoring at plasma membrane |
| NMDA selective glutamate receptor complex |
| synapse maturation |
| ionotropic glutamate receptor complex |
| excitatory synapse assembly |
| postsynaptic density organization |
| chemosensory behavior |
| vocalization behavior |
| postsynaptic specialization organization |
| dendritic spine morphogenesis |
| postsynapse assembly |
| reflex |
| receptor signaling complex adaptor activity |
| negative regulation of actin filament bundle assembly |
| regulation of AMPA receptor activity |
| positive regulation of excitatory postsynaptic potential |
| dendritic spine development |
| excitatory synapse |
| dendritic spine organization |
| long-term memory |
| positive regulation of synaptic transmission, glutamatergic |
| ionotropic glutamate receptor binding |
| brain morphogenesis |
| neuron projection organization |
| modulation of excitatory postsynaptic potential |
| neuromuscular junction development |
| positive regulation of dendritic spine development |
| long-term synaptic potentiation |
| social behavior |
| intraspecies interaction between organisms |
| neuromuscular process controlling balance |
| dendrite morphogenesis |
| scaffold protein binding |
| protein localization to synapse |
| positive regulation of nervous system process |
| regulation of glutamate receptor signaling pathway |
| multi-organism behavior |
| regulation of synaptic transmission, glutamatergic |
| regulation of dendritic spine development |
| positive regulation of dendrite development |
| regulation of neurotransmitter receptor activity |
| maintenance of protein location in cell |
| associative learning |
| Schaffer collateral - CA1 synapse |
| postsynapse organization |
| regulation of actin filament bundle assembly |
| synapse assembly |
| maintenance of location in cell |
| dendrite development |
| maintenance of protein location |
| neuromuscular process |
| memory |
| negative regulation of supramolecular fiber organization |
| SH3 domain binding |
| regulation of nervous system process |
| negative regulation of cytoskeleton organization |
| adult behavior |
| learning |
| dendritic spine |
| regulation of dendrite development |
| positive regulation of synaptic transmission |
| maintenance of location |
| regulation of cation channel activity |
| regulation of signaling receptor activity |
| regulation of synaptic plasticity |
| protein C-terminus binding |
| postsynaptic membrane |
| developmental maturation |
| postsynaptic density |
| regulation of ion transmembrane transporter activity |
| learning or memory |
| regulation of actin filament organization |
| regulation of transmembrane transporter activity |
| protein-containing complex binding |
| synapse organization |
| regulation of transporter activity |
| positive regulation of neuron projection development |
| cognition |
| neuron projection |
| regulation of cation transmembrane transport |
| regulation of actin cytoskeleton organization |
| glutamatergic synapse |
| regulation of supramolecular fiber organization |
| positive regulation of neuron differentiation |
| negative regulation of organelle organization |
| positive regulation of cell projection organization |
| regulation of actin filament-based process |
| developmental growth |
| growth |
| dendrite |
| regulation of membrane potential |
| cell morphogenesis involved in neuron differentiation |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| positive regulation of neurogenesis |
| regulation of ion transmembrane transport |
| neuron projection morphogenesis |
| plasma membrane bounded cell projection morphogenesis |
| cell projection morphogenesis |
| regulation of neuron projection development |
| cell part morphogenesis |
| positive regulation of nervous system development |
| regulation of cytoskeleton organization |
| positive regulation of cell development |
| cell junction |
| cell morphogenesis involved in differentiation |
| regulation of transmembrane transport |
| behavior |
| regulation of system process |
| regulation of neuron differentiation |
| neuron projection development |
| regulation of plasma membrane bounded cell projection organization |
| regulation of ion transport |
| negative regulation of cellular component organization |
| regulation of cell projection organization |
| cell morphogenesis |
| brain development |
| organelle assembly |
| head development |
| neuron development |
| regulation of neurogenesis |
| cellular component morphogenesis |
| regulation of nervous system development |
| regulation of cell development |
| animal organ morphogenesis |
| regulation of cellular component biogenesis |
| positive regulation of cell differentiation |
| sensory perception |
| central nervous system development |
| neuron differentiation |
| identical protein binding |
| cytoskeleton organization |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| positive regulation of cellular component organization |
| regulation of organelle organization |
| positive regulation of developmental process |
| nervous system process |
| generation of neurons |
| protein-containing complex assembly |
| cellular protein localization |
| cellular macromolecule localization |
| neurogenesis |
| cell development |
| positive regulation of signal transduction |
| positive regulation of multicellular organismal process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| protein-containing complex subunit organization |
| regulation of transport |
| system process |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 18936
- Expression level (log2 read counts): 5.49
Expression Distribution
SHANK1 Expression in NALM6 Cells: 5.49
