SHARPIN [The Human Chemical-Genetic Interaction Map Project]

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======= SHARPIN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SHARPIN
  * **<color #00a2e8>Official Name</color>**: SHANK associated RH domain interactor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=81858|81858]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H0F6|Q9H0F6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SHARPIN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SHARPIN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611885|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-RanBP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein linear polyubiquitination|
|LUBAC complex|
|regulation of CD40 signaling pathway|
|apoptotic nuclear changes|
|cellular component disassembly involved in execution phase of apoptosis|
|polyubiquitin modification-dependent protein binding|
|execution phase of apoptosis|
|regulation of tumor necrosis factor-mediated signaling pathway|
|I-kappaB kinase/NF-kappaB signaling|
|ubiquitin binding|
|negative regulation of inflammatory response|
|regulation of cytokine-mediated signaling pathway|
|regulation of response to cytokine stimulus|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|negative regulation of defense response|
|keratinization|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|ubiquitin-protein transferase activity|
|postsynaptic density|
|protein-containing complex binding|
|keratinocyte differentiation|
|protein polyubiquitination|
|epidermal cell differentiation|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|regulation of inflammatory response|
|protein homooligomerization|
|proteasomal protein catabolic process|
|negative regulation of response to external stimulus|
|skin development|
|cellular component disassembly|
|epidermis development|
|dendrite|
|mitochondrion organization|
|protein complex oligomerization|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|cell junction|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|epithelial cell differentiation|
|protein catabolic process|
|protein ubiquitination|
|brain development|
|regulation of defense response|
|protein modification by small protein conjugation|
|head development|
|cellular macromolecule catabolic process|
|apoptotic process|
|central nervous system development|
|protein modification by small protein conjugation or removal|
|positive regulation of intracellular signal transduction|
|macromolecule catabolic process|
|programmed cell death|
|organonitrogen compound catabolic process|
|identical protein binding|
|cell death|
|regulation of response to external stimulus|
|epithelium development|
|proteolysis|
|regulation of response to stress|
|protein-containing complex assembly|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|intracellular signal transduction|
|tissue development|
|organic substance catabolic process|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-1.79|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.586|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16809
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SHARPIN Expression in NALM6 Cells: 4.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>