SHARPIN
Gene Information
- Official Symbol: SHARPIN
- Official Name: SHANK associated RH domain interactor
- Aliases and Previous Symbols: N/A
- Entrez ID: 81858
- UniProt: Q9H0F6
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| zf-RanBP |
GO Terms
| protein linear polyubiquitination |
| LUBAC complex |
| regulation of CD40 signaling pathway |
| apoptotic nuclear changes |
| cellular component disassembly involved in execution phase of apoptosis |
| polyubiquitin modification-dependent protein binding |
| execution phase of apoptosis |
| regulation of tumor necrosis factor-mediated signaling pathway |
| I-kappaB kinase/NF-kappaB signaling |
| ubiquitin binding |
| negative regulation of inflammatory response |
| regulation of cytokine-mediated signaling pathway |
| regulation of response to cytokine stimulus |
| positive regulation of I-kappaB kinase/NF-kappaB signaling |
| negative regulation of defense response |
| keratinization |
| regulation of I-kappaB kinase/NF-kappaB signaling |
| ubiquitin-protein transferase activity |
| postsynaptic density |
| protein-containing complex binding |
| keratinocyte differentiation |
| protein polyubiquitination |
| epidermal cell differentiation |
| proteasome-mediated ubiquitin-dependent protein catabolic process |
| regulation of inflammatory response |
| protein homooligomerization |
| proteasomal protein catabolic process |
| negative regulation of response to external stimulus |
| skin development |
| cellular component disassembly |
| epidermis development |
| dendrite |
| mitochondrion organization |
| protein complex oligomerization |
| ubiquitin-dependent protein catabolic process |
| modification-dependent protein catabolic process |
| modification-dependent macromolecule catabolic process |
| cell junction |
| proteolysis involved in cellular protein catabolic process |
| cellular protein catabolic process |
| epithelial cell differentiation |
| protein catabolic process |
| protein ubiquitination |
| brain development |
| regulation of defense response |
| protein modification by small protein conjugation |
| head development |
| cellular macromolecule catabolic process |
| apoptotic process |
| central nervous system development |
| protein modification by small protein conjugation or removal |
| positive regulation of intracellular signal transduction |
| macromolecule catabolic process |
| programmed cell death |
| organonitrogen compound catabolic process |
| identical protein binding |
| cell death |
| regulation of response to external stimulus |
| epithelium development |
| proteolysis |
| regulation of response to stress |
| protein-containing complex assembly |
| negative regulation of response to stimulus |
| positive regulation of signal transduction |
| intracellular signal transduction |
| tissue development |
| organic substance catabolic process |
| cellular catabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| protein-containing complex subunit organization |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| TRAIL 5ng/ml R00 exp35 | -1.79 |
| Pterostilbene 16μM R02 exp78 | 1.75 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| RRM1 | 0.586 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 16809
- Expression level (log2 read counts): 4.45
Expression Distribution
SHARPIN Expression in NALM6 Cells: 4.45
