SHC2

Gene Information

Official Symbol: SHC2
Official Name: SHC adaptor protein 2
Aliases and Previous Symbols: N/A
Entrez ID: 25759
UniProt: P98077
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 4737
Expression level (log2 read counts): -3.42

Expression Distribution

PID
SH2

receptor tyrosine kinase binding
vascular endothelial growth factor receptor signaling pathway
activation of MAPK activity
Ras protein signal transduction
positive regulation of MAP kinase activity
small GTPase mediated signal transduction
activation of protein kinase activity
positive regulation of protein serine/threonine kinase activity
regulation of MAP kinase activity
MAPK cascade
signal transduction by protein phosphorylation
cellular component
transmembrane receptor protein tyrosine kinase signaling pathway
regulation of protein serine/threonine kinase activity
positive regulation of protein kinase activity
positive regulation of MAPK cascade
positive regulation of kinase activity
positive regulation of transferase activity
enzyme linked receptor protein signaling pathway
regulation of MAPK cascade
regulation of protein kinase activity
regulation of kinase activity
protein phosphorylation
regulation of transferase activity
positive regulation of protein phosphorylation
positive regulation of intracellular signal transduction
positive regulation of phosphorylation
positive regulation of phosphorus metabolic process
positive regulation of phosphate metabolic process
positive regulation of protein modification process
phosphorylation
positive regulation of catalytic activity
regulation of protein phosphorylation
regulation of phosphorylation
positive regulation of cellular protein metabolic process
positive regulation of signal transduction
intracellular signal transduction
positive regulation of protein metabolic process
positive regulation of molecular function
regulation of phosphate metabolic process