SIAH3

Gene Information

Official Symbol: SIAH3
Official Name: siah E3 ubiquitin protein ligase family member 3
Aliases and Previous Symbols: N/A
Entrez ID: 283514
UniProt: Q8IW03
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Negative regulator of PRKN translocation to damaged mitochondria. Acts probably by destabilizing PINK1 protein, hence inhibiting PRKN targeting to dysfunctional depolarized mitochondria. {ECO:0000269|PubMed:24270810}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 5892
Expression level (log2 read counts): 1.55

Expression Distribution

negative regulation of protein targeting to mitochondrion
negative regulation of establishment of protein localization to mitochondrion
ubiquitin conjugating enzyme binding
negative regulation of intracellular protein transport
regulation of protein targeting to mitochondrion
negative regulation of mitochondrion organization
negative regulation of intracellular transport
regulation of establishment of protein localization to mitochondrion
regulation of protein targeting
negative regulation of cellular protein localization
regulation of mitochondrion organization
negative regulation of protein transport
negative regulation of establishment of protein localization
ubiquitin protein ligase activity
regulation of intracellular protein transport
regulation of protein stability
proteasome-mediated ubiquitin-dependent protein catabolic process
proteasomal protein catabolic process
regulation of intracellular transport
negative regulation of organelle organization
negative regulation of transport
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
regulation of cellular protein localization
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
protein catabolic process
protein ubiquitination
negative regulation of cellular component organization
regulation of protein transport
regulation of peptide transport
regulation of establishment of protein localization
protein modification by small protein conjugation
cellular macromolecule catabolic process
regulation of cellular localization
protein modification by small protein conjugation or removal
regulation of protein localization
macromolecule catabolic process
organonitrogen compound catabolic process