SIK2

Entrez Summary: N/A
UniProt Summary: Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators. {ECO:0000269|PubMed:15454081}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Amiloride 100μM R08 exp447	-2.15
Cabazitaxel 0.001μM R05 exp223	1.8

Pkinase Tyr
Pkinase

nucleotide-activated protein kinase complex
cellular response to glucose starvation
negative regulation of TOR signaling
regulation of insulin receptor signaling pathway
regulation of cellular response to insulin stimulus
regulation of TOR signaling
cellular response to starvation
response to starvation
protein autophosphorylation
magnesium ion binding
cellular response to nutrient levels
cellular response to extracellular stimulus
cellular response to external stimulus
protein serine/threonine kinase activity
response to nutrient levels
negative regulation of intracellular signal transduction
response to extracellular stimulus
protein phosphorylation
negative regulation of signal transduction
phosphorylation
negative regulation of cell communication
negative regulation of signaling
ATP binding
negative regulation of response to stimulus
intracellular signal transduction
cellular response to stress
regulation of intracellular signal transduction