SIVA1 [The Human Chemical-Genetic Interaction Map Project]

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======= SIVA1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SIVA1
  * **<color #00a2e8>Official Name</color>**: SIVA1 apoptosis inducing factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10572|10572]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15304|O15304]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SIVA1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SIVA1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605567|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein with an important role in the apoptotic (programmed cell death) pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. The CD27 antigen cytoplasmic tail binds to the N-terminus of this protein. Two alternatively spliced transcript variants encoding distinct proteins have been described. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa- B and promotes T-cell receptor-mediated apoptosis. {ECO:0000269|PubMed:12011449, ECO:0000269|PubMed:14739602, ECO:0000269|PubMed:15034012, ECO:0000269|PubMed:15958577, ECO:0000269|PubMed:16491128}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Siva|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|CD27 receptor binding|
|tumor necrosis factor receptor binding|
|virus receptor activity|
|viral entry into host cell|
|extrinsic apoptotic signaling pathway|
|entry into host|
|entry into host cell|
|interaction with host|
|viral life cycle|
|apoptotic signaling pathway|
|viral process|
|symbiotic process|
|interspecies interaction between organisms|
|apoptotic process|
|programmed cell death|
|cell death|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-3.03|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-2.62|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|-2.47|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-2.37|
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|-2.06|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|1.75|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|1.75|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|1.83|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|2.18|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 6/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|2/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12244
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.79 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SIVA1 Expression in NALM6 Cells: 6.79'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>