SIVA1

Entrez Summary: This gene encodes a protein with an important role in the apoptotic (programmed cell death) pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. The CD27 antigen cytoplasmic tail binds to the N-terminus of this protein. Two alternatively spliced transcript variants encoding distinct proteins have been described. [provided by RefSeq, Jul 2008].
UniProt Summary: Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa- B and promotes T-cell receptor-mediated apoptosis. {ECO:0000269|PubMed:12011449, ECO:0000269|PubMed:14739602, ECO:0000269|PubMed:15034012, ECO:0000269|PubMed:15958577, ECO:0000269|PubMed:16491128}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Olaparib 4μM R08 exp512	-3.03
Rucaparib 6.5μM R08 exp520	-2.62
Ribavirin 10 to 15μM on day4 R04 exp160	-2.47
MLN-4924 0.2μM R00 exp21	-2.37
4-Nitroquinoline-1-oxide 0.5μM R08 exp446	-2.06
Bortezomib 0.005μM R00 exp6	1.75
Campthothecin 0.001μM R06 exp270	1.75
LY2090314 0.003μM R08 exp500 no dilution day6	1.83
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	2.18

Global Fraction of Cell Lines Where Essential: 6/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	2/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

CD27 receptor binding
tumor necrosis factor receptor binding
virus receptor activity
viral entry into host cell
extrinsic apoptotic signaling pathway
entry into host
entry into host cell
interaction with host
viral life cycle
apoptotic signaling pathway
viral process
symbiotic process
interspecies interaction between organisms
apoptotic process
programmed cell death
cell death