SKI [The Human Chemical-Genetic Interaction Map Project]

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======= SKI =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SKI
  * **<color #00a2e8>Official Name</color>**: SKI proto-oncogene
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6497|6497]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P12755|P12755]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SKI&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SKI|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/164780|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the nuclear protooncogene protein homolog of avian sarcoma viral (v-ski) oncogene. It functions as a repressor of TGF-beta signaling, and may play a role in neural tube development and muscle differentiation. [provided by RefSeq, Oct 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. Functions as a repressor of TGF-beta signaling. {ECO:0000269|PubMed:19049980}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ski Sno|
|c-SKI SMAD bind|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|histone deacetylase inhibitor activity|
|nose morphogenesis|
|regulation of Schwann cell proliferation|
|negative regulation of Schwann cell proliferation|
|negative regulation of histone deacetylation|
|negative regulation of activin receptor signaling pathway|
|negative regulation of glial cell proliferation|
|nose development|
|lens morphogenesis in camera-type eye|
|skeletal muscle fiber development|
|regulation of activin receptor signaling pathway|
|myelination in peripheral nervous system|
|peripheral nervous system axon ensheathment|
|myotube cell development|
|regulation of histone deacetylation|
|negative regulation of fibroblast proliferation|
|Schwann cell development|
|regulation of glial cell proliferation|
|face morphogenesis|
|protein homotrimerization|
|olfactory bulb development|
|olfactory lobe development|
|Schwann cell differentiation|
|head morphogenesis|
|repressing transcription factor binding|
|negative regulation of gliogenesis|
|negative regulation of histone modification|
|negative regulation of osteoblast differentiation|
|regulation of protein deacetylation|
|body morphogenesis|
|face development|
|negative regulation of BMP signaling pathway|
|anterior/posterior axis specification|
|SMAD binding|
|protein trimerization|
|positive regulation of DNA binding|
|SMAD protein signal transduction|
|transcriptional repressor complex|
|myotube differentiation|
|muscle fiber development|
|negative regulation of chromatin organization|
|somatic stem cell population maintenance|
|negative regulation of transforming growth factor beta receptor signaling pathway|
|negative regulation of ossification|
|peripheral nervous system development|
|negative regulation of cellular response to transforming growth factor beta stimulus|
|lens development in camera-type eye|
|regulation of fibroblast proliferation|
|axis specification|
|regulation of BMP signaling pathway|
|BMP signaling pathway|
|roof of mouth development|
|neural tube closure|
|tube closure|
|primary neural tube formation|
|PML body|
|transforming growth factor beta receptor signaling pathway|
|cellular response to BMP stimulus|
|response to BMP|
|neural tube formation|
|myelination|
|glial cell development|
|ensheathment of neurons|
|axon ensheathment|
|camera-type eye morphogenesis|
|regulation of osteoblast differentiation|
|regulation of transforming growth factor beta receptor signaling pathway|
|bone morphogenesis|
|regulation of cellular response to transforming growth factor beta stimulus|
|regulation of gliogenesis|
|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|skeletal muscle tissue development|
|embryonic epithelial tube formation|
|embryonic appendage morphogenesis|
|embryonic limb morphogenesis|
|regulation of DNA binding|
|epithelial tube formation|
|skeletal muscle organ development|
|negative regulation of chromosome organization|
|striated muscle cell development|
|stem cell population maintenance|
|maintenance of cell number|
|retina development in camera-type eye|
|morphogenesis of embryonic epithelium|
|regulation of histone modification|
|negative regulation of cellular response to growth factor stimulus|
|eye morphogenesis|
|tube formation|
|muscle cell development|
|limb morphogenesis|
|appendage morphogenesis|
|cellular response to transforming growth factor beta stimulus|
|neural tube development|
|response to transforming growth factor beta|
|glial cell differentiation|
|positive regulation of Wnt signaling pathway|
|positive regulation of binding|
|limb development|
|appendage development|
|regulation of chromatin organization|
|regulation of ossification|
|respiratory system development|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|bone development|
|striated muscle cell differentiation|
|transcription factor complex|
|gliogenesis|
|anterior/posterior pattern specification|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|skeletal system morphogenesis|
|transcription corepressor activity|
|protein domain specific binding|
|muscle cell differentiation|
|sensory organ morphogenesis|
|telencephalon development|
|regulation of cellular response to growth factor stimulus|
|nuclear body|
|striated muscle tissue development|
|negative regulation of neurogenesis|
|ubiquitin protein ligase binding|
|muscle organ development|
|muscle tissue development|
|epithelial tube morphogenesis|
|negative regulation of nervous system development|
|camera-type eye development|
|regionalization|
|negative regulation of cell development|
|protein homooligomerization|
|regulation of chromosome organization|
|eye development|
|regulation of Wnt signaling pathway|
|visual system development|
|sensory system development|
|negative regulation of organelle organization|
|regulation of binding|
|forebrain development|
|morphogenesis of an epithelium|
|pattern specification process|
|protein kinase binding|
|muscle structure development|
|centrosome|
|skeletal system development|
|cellular response to growth factor stimulus|
|protein complex oligomerization|
|response to growth factor|
|sensory organ development|
|tissue morphogenesis|
|embryonic morphogenesis|
|negative regulation of protein modification process|
|protein-containing complex|
|chordate embryonic development|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|embryo development ending in birth or egg hatching|
|RNA biosynthetic process|
|tube morphogenesis|
|negative regulation of cell population proliferation|
|negative regulation of cellular component organization|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|brain development|
|head development|
|neuron development|
|regulation of neurogenesis|
|zinc ion binding|
|tube development|
|negative regulation of transcription by RNA polymerase II|
|anatomical structure formation involved in morphogenesis|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|animal organ morphogenesis|
|embryo development|
|central nervous system development|
|neuron differentiation|
|negative regulation of cellular protein metabolic process|
|cell motility|
|localization of cell|
|nucleobase-containing compound biosynthetic process|
|negative regulation of protein metabolic process|
|epithelium development|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|regulation of organelle organization|
|organic cyclic compound biosynthetic process|
|locomotion|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|protein-containing complex assembly|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|positive regulation of signal transduction|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|tissue development|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-2.08|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|-1.88|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-1.73|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-1.72|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|-1.71|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|-1.7|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|1.93|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.462|
|[[:human genes:r:rrm1|RRM1]]|0.451|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2482
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.25 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SKI Expression in NALM6 Cells: 3.25'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>