SKI
Gene Information
- Official Symbol: SKI
- Official Name: SKI proto-oncogene
- Aliases and Previous Symbols: N/A
- Entrez ID: 6497
- UniProt: P12755
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes the nuclear protooncogene protein homolog of avian sarcoma viral (v-ski) oncogene. It functions as a repressor of TGF-beta signaling, and may play a role in neural tube development and muscle differentiation. [provided by RefSeq, Oct 2009].
- UniProt Summary: May play a role in terminal differentiation of skeletal muscle cells but not in the determination of cells to the myogenic lineage. Functions as a repressor of TGF-beta signaling. {ECO:0000269|PubMed:19049980}.
Pfam Domains GO Terms
Pfam Domains
| Ski Sno |
| c-SKI SMAD bind |
GO Terms
| histone deacetylase inhibitor activity |
| nose morphogenesis |
| regulation of Schwann cell proliferation |
| negative regulation of Schwann cell proliferation |
| negative regulation of histone deacetylation |
| negative regulation of activin receptor signaling pathway |
| negative regulation of glial cell proliferation |
| nose development |
| lens morphogenesis in camera-type eye |
| skeletal muscle fiber development |
| regulation of activin receptor signaling pathway |
| myelination in peripheral nervous system |
| peripheral nervous system axon ensheathment |
| myotube cell development |
| regulation of histone deacetylation |
| negative regulation of fibroblast proliferation |
| Schwann cell development |
| regulation of glial cell proliferation |
| face morphogenesis |
| protein homotrimerization |
| olfactory bulb development |
| olfactory lobe development |
| Schwann cell differentiation |
| head morphogenesis |
| repressing transcription factor binding |
| negative regulation of gliogenesis |
| negative regulation of histone modification |
| negative regulation of osteoblast differentiation |
| regulation of protein deacetylation |
| body morphogenesis |
| face development |
| negative regulation of BMP signaling pathway |
| anterior/posterior axis specification |
| SMAD binding |
| protein trimerization |
| positive regulation of DNA binding |
| SMAD protein signal transduction |
| transcriptional repressor complex |
| myotube differentiation |
| muscle fiber development |
| negative regulation of chromatin organization |
| somatic stem cell population maintenance |
| negative regulation of transforming growth factor beta receptor signaling pathway |
| negative regulation of ossification |
| peripheral nervous system development |
| negative regulation of cellular response to transforming growth factor beta stimulus |
| lens development in camera-type eye |
| regulation of fibroblast proliferation |
| axis specification |
| regulation of BMP signaling pathway |
| BMP signaling pathway |
| roof of mouth development |
| neural tube closure |
| tube closure |
| primary neural tube formation |
| PML body |
| transforming growth factor beta receptor signaling pathway |
| cellular response to BMP stimulus |
| response to BMP |
| neural tube formation |
| myelination |
| glial cell development |
| ensheathment of neurons |
| axon ensheathment |
| camera-type eye morphogenesis |
| regulation of osteoblast differentiation |
| regulation of transforming growth factor beta receptor signaling pathway |
| bone morphogenesis |
| regulation of cellular response to transforming growth factor beta stimulus |
| regulation of gliogenesis |
| negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| skeletal muscle tissue development |
| embryonic epithelial tube formation |
| embryonic appendage morphogenesis |
| embryonic limb morphogenesis |
| regulation of DNA binding |
| epithelial tube formation |
| skeletal muscle organ development |
| negative regulation of chromosome organization |
| striated muscle cell development |
| stem cell population maintenance |
| maintenance of cell number |
| retina development in camera-type eye |
| morphogenesis of embryonic epithelium |
| regulation of histone modification |
| negative regulation of cellular response to growth factor stimulus |
| eye morphogenesis |
| tube formation |
| muscle cell development |
| limb morphogenesis |
| appendage morphogenesis |
| cellular response to transforming growth factor beta stimulus |
| neural tube development |
| response to transforming growth factor beta |
| glial cell differentiation |
| positive regulation of Wnt signaling pathway |
| positive regulation of binding |
| limb development |
| appendage development |
| regulation of chromatin organization |
| regulation of ossification |
| respiratory system development |
| transmembrane receptor protein serine/threonine kinase signaling pathway |
| bone development |
| striated muscle cell differentiation |
| transcription factor complex |
| gliogenesis |
| anterior/posterior pattern specification |
| regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| skeletal system morphogenesis |
| transcription corepressor activity |
| protein domain specific binding |
| muscle cell differentiation |
| sensory organ morphogenesis |
| telencephalon development |
| regulation of cellular response to growth factor stimulus |
| nuclear body |
| striated muscle tissue development |
| negative regulation of neurogenesis |
| ubiquitin protein ligase binding |
| muscle organ development |
| muscle tissue development |
| epithelial tube morphogenesis |
| negative regulation of nervous system development |
| camera-type eye development |
| regionalization |
| negative regulation of cell development |
| protein homooligomerization |
| regulation of chromosome organization |
| eye development |
| regulation of Wnt signaling pathway |
| visual system development |
| sensory system development |
| negative regulation of organelle organization |
| regulation of binding |
| forebrain development |
| morphogenesis of an epithelium |
| pattern specification process |
| protein kinase binding |
| muscle structure development |
| centrosome |
| skeletal system development |
| cellular response to growth factor stimulus |
| protein complex oligomerization |
| response to growth factor |
| sensory organ development |
| tissue morphogenesis |
| embryonic morphogenesis |
| negative regulation of protein modification process |
| protein-containing complex |
| chordate embryonic development |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| embryo development ending in birth or egg hatching |
| RNA biosynthetic process |
| tube morphogenesis |
| negative regulation of cell population proliferation |
| negative regulation of cellular component organization |
| negative regulation of cell differentiation |
| enzyme linked receptor protein signaling pathway |
| brain development |
| head development |
| neuron development |
| regulation of neurogenesis |
| zinc ion binding |
| tube development |
| negative regulation of transcription by RNA polymerase II |
| anatomical structure formation involved in morphogenesis |
| regulation of nervous system development |
| regulation of cell development |
| negative regulation of developmental process |
| animal organ morphogenesis |
| embryo development |
| central nervous system development |
| neuron differentiation |
| negative regulation of cellular protein metabolic process |
| cell motility |
| localization of cell |
| nucleobase-containing compound biosynthetic process |
| negative regulation of protein metabolic process |
| epithelium development |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| positive regulation of transcription by RNA polymerase II |
| cellular response to endogenous stimulus |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of signal transduction |
| regulation of organelle organization |
| organic cyclic compound biosynthetic process |
| locomotion |
| negative regulation of RNA metabolic process |
| negative regulation of cell communication |
| negative regulation of signaling |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| negative regulation of cellular biosynthetic process |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| movement of cell or subcellular component |
| protein-containing complex assembly |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| neurogenesis |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cell development |
| positive regulation of signal transduction |
| RNA metabolic process |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| tissue development |
| macromolecule biosynthetic process |
| positive regulation of molecular function |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of protein modification process |
| protein-containing complex subunit organization |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Artemisinin 50μM R08 exp450 | -2.08 |
| GSK461364A 0.1μM R03 exp126 | -1.88 |
| Milciclib 2μM R08 exp502 | -1.73 |
| BI-D1870 3.15μM R02 exp66 | -1.72 |
| CCCP 0.1μM R00 exp10 | -1.71 |
| Bleomycin 5μM R08 exp459 | -1.7 |
| S-trityl-L-cysteine 0.5μM R05 exp243 | 1.93 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 1/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 2482
- Expression level (log2 read counts): 3.25
Expression Distribution
SKI Expression in NALM6 Cells: 3.25
