SKIV2L [The Human Chemical-Genetic Interaction Map Project]

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======= SKIV2L =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SKIV2L
  * **<color #00a2e8>Official Name</color>**: Ski2 like RNA helicase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6499|6499]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15477|Q15477]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SKIV2L&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SKIV2L|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a human homologue of yeast SKI2 and may be involved in antiviral activity by blocking translation of poly(A) deficient mRNAs. This gene is located in the class III region of the major histocompatibility complex. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Helicase; has ATPase activity. Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C).

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DEAD|
|Helicase C|
|DSHCT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nuclear-transcribed mRNA catabolic process, 3-5 exonucleolytic nonsense-mediated decay|
|Ski complex|
|nuclear-transcribed mRNA catabolic process, exonucleolytic, 3-5|
|exonucleolytic catabolism of deadenylated mRNA|
|nuclear-transcribed mRNA catabolic process, exonucleolytic|
|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|
|RNA helicase activity|
|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|
|nuclear-transcribed mRNA catabolic process|
|mRNA catabolic process|
|RNA catabolic process|
|nucleobase-containing compound catabolic process|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|organic cyclic compound catabolic process|
|mRNA metabolic process|
|cellular macromolecule catabolic process|
|macromolecule catabolic process|
|RNA binding|
|ATP binding|
|RNA metabolic process|
|negative regulation of gene expression|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp453|B02 10μM R08 exp453]]|-2.7|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|-2.38|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-1.82|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|1.71|
|[[:results:exp274|Citral 50μM R06 exp274]]|1.74|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.74|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|1.74|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|1.89|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.91|
|[[:results:exp519|RS-1 10μM R08 exp519]]|1.91|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.93|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|1.95|
|[[:results:exp303|39°C R06 exp303]]|1.97|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|2.02|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|2.04|
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|2.09|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|2.13|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.16|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|2.31|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|2.31|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|2.66|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5053
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SKIV2L Expression in NALM6 Cells: 6.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>