SKIV2L
Gene Information
- Official Symbol: SKIV2L
- Official Name: Ski2 like RNA helicase
- Aliases and Previous Symbols: N/A
- Entrez ID: 6499
- UniProt: Q15477
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: N/A
Function Summary
- Entrez Summary: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a human homologue of yeast SKI2 and may be involved in antiviral activity by blocking translation of poly(A) deficient mRNAs. This gene is located in the class III region of the major histocompatibility complex. [provided by RefSeq, Jul 2008].
- UniProt Summary: Helicase; has ATPase activity. Component of the SKI complex which is thought to be involved in exosome-mediated RNA decay and associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C).
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 5053
- Expression level (log2 read counts): 6.11
SKIV2L Expression in NALM6 Cells: 6.11
