SLA2 [The Human Chemical-Genetic Interaction Map Project]

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======= SLA2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLA2
  * **<color #00a2e8>Official Name</color>**: Src like adaptor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84174|84174]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H6Q3|Q9H6Q3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLA2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLA2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606577|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the SLAP family of adapter proteins. The encoded protein may play an important receptor-proximal role in downregulating T and B cell-mediated responses and inhibits antigen receptor-induced calcium mobilization. This protein interacts with Cas-Br-M (murine) ecotropic retroviral transforming sequence c. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SH2|
|SH3 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|1-phosphatidylinositol-3-kinase regulator activity|
|phosphatidylinositol 3-kinase complex|
|negative regulation of B cell activation|
|negative regulation of calcium-mediated signaling|
|negative regulation of insulin receptor signaling pathway|
|negative regulation of cellular response to insulin stimulus|
|phosphatidylinositol phosphorylation|
|regulation of phosphatidylinositol 3-kinase activity|
|SH3/SH2 adaptor activity|
|regulation of lipid kinase activity|
|regulation of insulin receptor signaling pathway|
|lipid phosphorylation|
|regulation of cellular response to insulin stimulus|
|regulation of phospholipid metabolic process|
|regulation of calcium-mediated signaling|
|protein N-terminus binding|
|late endosome|
|negative regulation of lymphocyte activation|
|intracellular receptor signaling pathway|
|phosphatidylinositol metabolic process|
|negative regulation of leukocyte activation|
|negative regulation of cell activation|
|lipid modification|
|regulation of B cell activation|
|B cell mediated immunity|
|endosome membrane|
|T cell activation|
|lymphocyte mediated immunity|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|antigen receptor-mediated signaling pathway|
|glycerophospholipid metabolic process|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|lymphocyte activation|
|regulation of lipid metabolic process|
|negative regulation of immune system process|
|immune response-activating cell surface receptor signaling pathway|
|immune response-regulating cell surface receptor signaling pathway|
|negative regulation of intracellular signal transduction|
|regulation of lymphocyte activation|
|immune response-activating signal transduction|
|immune response-regulating signaling pathway|
|regulation of leukocyte activation|
|adaptive immune response|
|activation of immune response|
|regulation of cell activation|
|intracellular membrane-bounded organelle|
|leukocyte mediated immunity|
|negative regulation of transcription by RNA polymerase II|
|positive regulation of immune response|
|regulation of kinase activity|
|organophosphate metabolic process|
|leukocyte activation|
|cellular lipid metabolic process|
|regulation of transferase activity|
|Golgi apparatus|
|cell activation|
|immune effector process|
|regulation of immune response|
|positive regulation of immune system process|
|negative regulation of transcription, DNA-templated|
|lipid metabolic process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|phosphorylation|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|regulation of phosphorylation|
|negative regulation of response to stimulus|
|regulation of immune system process|
|positive regulation of signal transduction|
|negative regulation of gene expression|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5766
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.19 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLA2 Expression in NALM6 Cells: 2.19'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>