SLA2

Gene Information

Official Symbol: SLA2
Official Name: Src like adaptor 2
Aliases and Previous Symbols: N/A
Entrez ID: 84174
UniProt: Q9H6Q3
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the SLAP family of adapter proteins. The encoded protein may play an important receptor-proximal role in downregulating T and B cell-mediated responses and inhibits antigen receptor-induced calcium mobilization. This protein interacts with Cas-Br-M (murine) ecotropic retroviral transforming sequence c. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 5766
Expression level (log2 read counts): 2.19

Expression Distribution

SH2
SH3 1

1-phosphatidylinositol-3-kinase regulator activity
phosphatidylinositol 3-kinase complex
negative regulation of B cell activation
negative regulation of calcium-mediated signaling
negative regulation of insulin receptor signaling pathway
negative regulation of cellular response to insulin stimulus
phosphatidylinositol phosphorylation
regulation of phosphatidylinositol 3-kinase activity
SH3/SH2 adaptor activity
regulation of lipid kinase activity
regulation of insulin receptor signaling pathway
lipid phosphorylation
regulation of cellular response to insulin stimulus
regulation of phospholipid metabolic process
regulation of calcium-mediated signaling
protein N-terminus binding
late endosome
negative regulation of lymphocyte activation
intracellular receptor signaling pathway
phosphatidylinositol metabolic process
negative regulation of leukocyte activation
negative regulation of cell activation
lipid modification
regulation of B cell activation
B cell mediated immunity
endosome membrane
T cell activation
lymphocyte mediated immunity
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
antigen receptor-mediated signaling pathway
glycerophospholipid metabolic process
phospholipid metabolic process
glycerolipid metabolic process
lymphocyte activation
regulation of lipid metabolic process
negative regulation of immune system process
immune response-activating cell surface receptor signaling pathway
immune response-regulating cell surface receptor signaling pathway
negative regulation of intracellular signal transduction
regulation of lymphocyte activation