SLAMF8 [The Human Chemical-Genetic Interaction Map Project]

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======= SLAMF8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLAMF8
  * **<color #00a2e8>Official Name</color>**: SLAM family member 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=56833|56833]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9P0V8|Q9P0V8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLAMF8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLAMF8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606620|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in B-lineage commitment and/or modulation of signaling through the B-cell receptor. {ECO:0000269|PubMed:11313408}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|B-1 B cell lineage commitment|
|negative regulation of dendritic cell chemotaxis|
|negative regulation of neutrophil migration|
|leukocyte chemotaxis involved in inflammatory response|
|B-1 B cell differentiation|
|negative regulation of respiratory burst involved in inflammatory response|
|B cell lineage commitment|
|regulation of respiratory burst involved in inflammatory response|
|negative regulation of respiratory burst|
|negative regulation of monocyte chemotaxis|
|negative regulation of macrophage chemotaxis|
|negative regulation of mononuclear cell migration|
|regulation of dendritic cell chemotaxis|
|negative regulation of macrophage migration|
|regulation of NAD(P)H oxidase activity|
|leukocyte migration involved in inflammatory response|
|regulation of respiratory burst|
|negative regulation of leukocyte chemotaxis|
|mature B cell differentiation|
|regulation of monocyte chemotaxis|
|regulation of macrophage chemotaxis|
|regulation of B cell differentiation|
|phagosome acidification|
|regulation of neutrophil migration|
|regulation of macrophage migration|
|phagosome maturation|
|negative regulation of leukocyte migration|
|intracellular pH reduction|
|regulation of mononuclear cell migration|
|pH reduction|
|negative regulation of innate immune response|
|negative regulation of chemotaxis|
|regulation of intracellular pH|
|regulation of cellular pH|
|negative regulation of response to biotic stimulus|
|regulation of oxidoreductase activity|
|regulation of pH|
|B cell differentiation|
|cellular monovalent inorganic cation homeostasis|
|regulation of leukocyte chemotaxis|
|negative regulation of immune effector process|
|negative regulation of inflammatory response|
|monovalent inorganic cation homeostasis|
|leukocyte chemotaxis|
|negative regulation of immune response|
|B cell activation|
|regulation of lymphocyte differentiation|
|regulation of leukocyte migration|
|signaling receptor activity|
|negative regulation of defense response|
|regulation of B cell activation|
|cell chemotaxis|
|regulation of chemotaxis|
|negative regulation of multi-organism process|
|lymphocyte differentiation|
|cell fate commitment|
|negative regulation of cell migration|
|regulation of leukocyte differentiation|
|negative regulation of cell motility|
|negative regulation of cellular component movement|
|negative regulation of locomotion|
|defense response to bacterium|
|leukocyte differentiation|
|regulation of inflammatory response|
|negative regulation of response to external stimulus|
|leukocyte migration|
|lymphocyte activation|
|cellular response to drug|
|negative regulation of immune system process|
|regulation of hemopoiesis|
|regulation of innate immune response|
|regulation of immune effector process|
|inflammatory response|
|regulation of lymphocyte activation|
|regulation of response to biotic stimulus|
|chemotaxis|
|taxis|
|hemopoiesis|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|cell surface|
|cellular cation homeostasis|
|regulation of cell activation|
|cellular ion homeostasis|
|immune system development|
|response to bacterium|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|regulation of defense response|
|regulation of multi-organism process|
|ion homeostasis|
|regulation of cell migration|
|regulation of kinase activity|
|cellular homeostasis|
|regulation of cell motility|
|leukocyte activation|
|regulation of cell development|
|defense response to other organism|
|cell migration|
|regulation of transferase activity|
|regulation of locomotion|
|regulation of cellular component movement|
|response to drug|
|identical protein binding|
|cell activation|
|cell motility|
|localization of cell|
|regulation of response to external stimulus|
|chemical homeostasis|
|regulation of immune response|
|negative regulation of multicellular organismal process|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|defense response|
|regulation of response to stress|
|movement of cell or subcellular component|
|regulation of phosphorylation|
|negative regulation of response to stimulus|
|homeostatic process|
|regulation of immune system process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-1.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2721
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLAMF8 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>