SLAMF8
Gene Information
- Official Symbol: SLAMF8
- Official Name: SLAM family member 8
- Aliases and Previous Symbols: N/A
- Entrez ID: 56833
- UniProt: Q9P0V8
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: May play a role in B-lineage commitment and/or modulation of signaling through the B-cell receptor. {ECO:0000269|PubMed:11313408}.
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| B-1 B cell lineage commitment |
| negative regulation of dendritic cell chemotaxis |
| negative regulation of neutrophil migration |
| leukocyte chemotaxis involved in inflammatory response |
| B-1 B cell differentiation |
| negative regulation of respiratory burst involved in inflammatory response |
| B cell lineage commitment |
| regulation of respiratory burst involved in inflammatory response |
| negative regulation of respiratory burst |
| negative regulation of monocyte chemotaxis |
| negative regulation of macrophage chemotaxis |
| negative regulation of mononuclear cell migration |
| regulation of dendritic cell chemotaxis |
| negative regulation of macrophage migration |
| regulation of NAD(P)H oxidase activity |
| leukocyte migration involved in inflammatory response |
| regulation of respiratory burst |
| negative regulation of leukocyte chemotaxis |
| mature B cell differentiation |
| regulation of monocyte chemotaxis |
| regulation of macrophage chemotaxis |
| regulation of B cell differentiation |
| phagosome acidification |
| regulation of neutrophil migration |
| regulation of macrophage migration |
| phagosome maturation |
| negative regulation of leukocyte migration |
| intracellular pH reduction |
| regulation of mononuclear cell migration |
| pH reduction |
| negative regulation of innate immune response |
| negative regulation of chemotaxis |
| regulation of intracellular pH |
| regulation of cellular pH |
| negative regulation of response to biotic stimulus |
| regulation of oxidoreductase activity |
| regulation of pH |
| B cell differentiation |
| cellular monovalent inorganic cation homeostasis |
| regulation of leukocyte chemotaxis |
| negative regulation of immune effector process |
| negative regulation of inflammatory response |
| monovalent inorganic cation homeostasis |
| leukocyte chemotaxis |
| negative regulation of immune response |
| B cell activation |
| regulation of lymphocyte differentiation |
| regulation of leukocyte migration |
| signaling receptor activity |
| negative regulation of defense response |
| regulation of B cell activation |
| cell chemotaxis |
| regulation of chemotaxis |
| negative regulation of multi-organism process |
| lymphocyte differentiation |
| cell fate commitment |
| negative regulation of cell migration |
| regulation of leukocyte differentiation |
| negative regulation of cell motility |
| negative regulation of cellular component movement |
| negative regulation of locomotion |
| defense response to bacterium |
| leukocyte differentiation |
| regulation of inflammatory response |
| negative regulation of response to external stimulus |
| leukocyte migration |
| lymphocyte activation |
| cellular response to drug |
| negative regulation of immune system process |
| regulation of hemopoiesis |
| regulation of innate immune response |
| regulation of immune effector process |
| inflammatory response |
| regulation of lymphocyte activation |
| regulation of response to biotic stimulus |
| chemotaxis |
| taxis |
| hemopoiesis |
| regulation of leukocyte activation |
| hematopoietic or lymphoid organ development |
| cell surface |
| cellular cation homeostasis |
| regulation of cell activation |
| cellular ion homeostasis |
| immune system development |
| response to bacterium |
| cation homeostasis |
| inorganic ion homeostasis |
| cellular chemical homeostasis |
| regulation of defense response |
| regulation of multi-organism process |
| ion homeostasis |
| regulation of cell migration |
| regulation of kinase activity |
| cellular homeostasis |
| regulation of cell motility |
| leukocyte activation |
| regulation of cell development |
| defense response to other organism |
| cell migration |
| regulation of transferase activity |
| regulation of locomotion |
| regulation of cellular component movement |
| response to drug |
| identical protein binding |
| cell activation |
| cell motility |
| localization of cell |
| regulation of response to external stimulus |
| chemical homeostasis |
| regulation of immune response |
| negative regulation of multicellular organismal process |
| response to other organism |
| response to external biotic stimulus |
| locomotion |
| response to biotic stimulus |
| defense response |
| regulation of response to stress |
| movement of cell or subcellular component |
| regulation of phosphorylation |
| negative regulation of response to stimulus |
| homeostatic process |
| regulation of immune system process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| 5-Fluorouracil 20μM R00 exp2 | -1.81 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 2721
- Expression level (log2 read counts): -7.68
Expression Distribution
SLAMF8 Expression in NALM6 Cells: -7.68
