SLC10A1 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC10A1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC10A1
  * **<color #00a2e8>Official Name</color>**: solute carrier family 10 member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6554|6554]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14973|Q14973]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC10A1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC10A1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/182396|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SBF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|bile acid:sodium symporter activity|
|bile acid and bile salt transport|
|virus receptor activity|
|viral entry into host cell|
|entry into host cell|
|entry into host|
|monocarboxylic acid transport|
|organic hydroxy compound transport|
|sodium ion transport|
|interaction with host|
|basolateral plasma membrane|
|viral life cycle|
|organic acid transport|
|carboxylic acid transport|
|lipid transport|
|lipid localization|
|monovalent inorganic cation transport|
|organic anion transport|
|anion transport|
|metal ion transport|
|viral process|
|symbiotic process|
|interspecies interaction between organisms|
|cation transport|
|transmembrane transport|
|ion transport|
|integral component of plasma membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-1.89|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|1.7|
|[[:results:exp16|DABN 2μM R00 exp16]]|1.7|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|1.74|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|1.88|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|2|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|2.01|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|2.04|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9290
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC10A1 Expression in NALM6 Cells: -0.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>