SLC12A5 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC12A5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC12A5
  * **<color #00a2e8>Official Name</color>**: solute carrier family 12 member 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57468|57468]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H2X9|Q9H2X9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC12A5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC12A5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606726|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  K-Cl cotransporters are proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The protein encoded by this gene is an integral membrane K-Cl cotransporter that can function in either a net efflux or influx pathway, depending on the chemical concentration gradients of potassium and chloride. The encoded protein can act as a homomultimer, or as a heteromultimer with other K-Cl cotransporters, to maintain chloride homeostasis in neurons. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Sep 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis. As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition (By similarity). Involved in the regulation of dendritic spine formation and maturation (PubMed:24668262). {ECO:0000250|UniProtKB:Q63633, ECO:0000269|PubMed:24668262}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|AA permease|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|thermosensory behavior|
|cellular chloride ion homeostasis|
|potassium:chloride symporter activity|
|hypotonic response|
|cellular anion homeostasis|
|cellular monovalent inorganic anion homeostasis|
|chloride ion homeostasis|
|chloride transmembrane transporter activity|
|monovalent inorganic anion homeostasis|
|cell volume homeostasis|
|dendritic spine development|
|potassium ion homeostasis|
|potassium ion import across plasma membrane|
|anion homeostasis|
|inorganic cation import across plasma membrane|
|inorganic ion import across plasma membrane|
|response to osmotic stress|
|multicellular organism growth|
|chloride transmembrane transport|
|import across plasma membrane|
|chloride transport|
|dendrite development|
|inorganic anion transmembrane transport|
|monovalent inorganic cation homeostasis|
|learning|
|inorganic anion transport|
|potassium ion transmembrane transport|
|potassium ion transport|
|response to temperature stimulus|
|regulation of cell size|
|learning or memory|
|anion transmembrane transport|
|cognition|
|regulation of cellular component size|
|developmental growth|
|growth|
|monovalent inorganic cation transport|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|trans-synaptic signaling|
|synaptic signaling|
|regulation of anatomical structure size|
|inorganic cation transmembrane transport|
|behavior|
|anion transport|
|cation transmembrane transport|
|metal ion homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|neuron projection development|
|import into cell|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|neuron development|
|cation transport|
|cellular homeostasis|
|ion transmembrane transport|
|neuron differentiation|
|response to drug|
|chemical homeostasis|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|response to abiotic stimulus|
|transmembrane transport|
|ion transport|
|nervous system process|
|integral component of plasma membrane|
|generation of neurons|
|neurogenesis|
|homeostatic process|
|cell development|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp433|LJH685 50μM R08 exp433]]|1.74|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|1.77|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|1.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9443
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC12A5 Expression in NALM6 Cells: 1.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>