SLC12A5

Entrez Summary: K-Cl cotransporters are proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The protein encoded by this gene is an integral membrane K-Cl cotransporter that can function in either a net efflux or influx pathway, depending on the chemical concentration gradients of potassium and chloride. The encoded protein can act as a homomultimer, or as a heteromultimer with other K-Cl cotransporters, to maintain chloride homeostasis in neurons. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Sep 2008].
UniProt Summary: Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis. As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition (By similarity). Involved in the regulation of dendritic spine formation and maturation (PubMed:24668262). {ECO:0000250|UniProtKB:Q63633, ECO:0000269|PubMed:24668262}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

thermosensory behavior
cellular chloride ion homeostasis
potassium:chloride symporter activity
hypotonic response
cellular anion homeostasis
cellular monovalent inorganic anion homeostasis
chloride ion homeostasis
chloride transmembrane transporter activity
monovalent inorganic anion homeostasis
cell volume homeostasis
dendritic spine development
potassium ion homeostasis
potassium ion import across plasma membrane
anion homeostasis
inorganic cation import across plasma membrane
inorganic ion import across plasma membrane
response to osmotic stress
multicellular organism growth
chloride transmembrane transport
import across plasma membrane
chloride transport
dendrite development
inorganic anion transmembrane transport
monovalent inorganic cation homeostasis
learning
inorganic anion transport
potassium ion transmembrane transport
potassium ion transport
response to temperature stimulus
regulation of cell size
learning or memory
anion transmembrane transport
cognition
regulation of cellular component size
developmental growth
growth
monovalent inorganic cation transport
chemical synaptic transmission
anterograde trans-synaptic signaling
trans-synaptic signaling