SLC12A6 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC12A6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC12A6
  * **<color #00a2e8>Official Name</color>**: solute carrier family 12 member 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9990|9990]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UHW9|Q9UHW9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC12A6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC12A6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604878|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the K-Cl cotransporter (KCC) family. K-Cl cotransporters are integral membrane proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The proteins encoded by this gene are activated by cell swelling induced by hypotonic conditions. Alternate splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are associated with agenesis of the corpus callosum with peripheral neuropathy. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|AA permease|
|KCl Cotrans 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|hypotonic salinity response|
|cellular hypotonic salinity response|
|cellular hypotonic response|
|cellular response to salt stress|
|potassium:chloride symporter activity|
|hypotonic response|
|chloride ion homeostasis|
|response to salt stress|
|monovalent inorganic anion homeostasis|
|cell volume homeostasis|
|potassium ion homeostasis|
|cellular response to osmotic stress|
|potassium ion import across plasma membrane|
|anion homeostasis|
|inorganic ion import across plasma membrane|
|inorganic cation import across plasma membrane|
|response to osmotic stress|
|chloride transmembrane transport|
|import across plasma membrane|
|chloride transport|
|inorganic anion transmembrane transport|
|monovalent inorganic cation homeostasis|
|potassium ion transmembrane transport|
|inorganic anion transport|
|potassium ion transport|
|regulation of cell size|
|basolateral plasma membrane|
|anion transmembrane transport|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|angiogenesis|
|regulation of cellular component size|
|monovalent inorganic cation transport|
|blood vessel morphogenesis|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|trans-synaptic signaling|
|synaptic signaling|
|blood vessel development|
|vasculature development|
|regulation of anatomical structure size|
|cardiovascular system development|
|inorganic cation transmembrane transport|
|anion transport|
|cation transmembrane transport|
|metal ion homeostasis|
|metal ion transport|
|inorganic ion transmembrane transport|
|tube morphogenesis|
|import into cell|
|cation homeostasis|
|inorganic ion homeostasis|
|ion homeostasis|
|cation transport|
|tube development|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|cellular homeostasis|
|ion transmembrane transport|
|chemical homeostasis|
|cell-cell signaling|
|response to abiotic stimulus|
|transmembrane transport|
|ion transport|
|integral component of plasma membrane|
|homeostatic process|
|cellular response to stress|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp111|R-DABN 8μM R03 exp111]]|-1.83|
|[[:results:exp401|SNS-032 25μM R07 exp401]]|1.75|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|1.92|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.58|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11237
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC12A6 Expression in NALM6 Cells: 6.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>