SLC12A6

Entrez Summary: This gene is a member of the K-Cl cotransporter (KCC) family. K-Cl cotransporters are integral membrane proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The proteins encoded by this gene are activated by cell swelling induced by hypotonic conditions. Alternate splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are associated with agenesis of the corpus callosum with peripheral neuropathy. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

AA permease
KCl Cotrans 1

hypotonic salinity response
cellular hypotonic salinity response
cellular hypotonic response
cellular response to salt stress
potassium:chloride symporter activity
hypotonic response
chloride ion homeostasis
response to salt stress
monovalent inorganic anion homeostasis
cell volume homeostasis
potassium ion homeostasis
cellular response to osmotic stress
potassium ion import across plasma membrane
anion homeostasis
inorganic ion import across plasma membrane
inorganic cation import across plasma membrane
response to osmotic stress
chloride transmembrane transport
import across plasma membrane
chloride transport
inorganic anion transmembrane transport
monovalent inorganic cation homeostasis
potassium ion transmembrane transport
inorganic anion transport
potassium ion transport
regulation of cell size
basolateral plasma membrane
anion transmembrane transport
cellular response to environmental stimulus
cellular response to abiotic stimulus
angiogenesis
regulation of cellular component size
monovalent inorganic cation transport
blood vessel morphogenesis
anterograde trans-synaptic signaling
chemical synaptic transmission
trans-synaptic signaling
synaptic signaling
blood vessel development
vasculature development