SLC15A4

Entrez Summary: N/A
UniProt Summary: Proton oligopeptide cotransporter. Transports free histidine and certain di- and tripeptides. {ECO:0000269|PubMed:16289537}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

MFS 1
PTR2

histidine transport
L-histidine transmembrane transporter activity
L-histidine transmembrane transport
peptide:proton symporter activity
oligopeptide transmembrane transporter activity
oligopeptide transmembrane transport
oligopeptide transport
peptide transmembrane transporter activity
aromatic amino acid transport
basic amino acid transport
azole transport
L-alpha-amino acid transmembrane transport
L-amino acid transport
drug transmembrane transport
amino acid transmembrane transport
specific granule membrane
amino acid transport
carboxylic acid transmembrane transport
organic acid transmembrane transport
proton transmembrane transport
drug transport
anion transmembrane transport
organic acid transport
carboxylic acid transport
lysosomal membrane
monovalent inorganic cation transport
organic anion transport
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
inorganic cation transmembrane transport
anion transport
myeloid leukocyte activation
cation transmembrane transport
leukocyte activation involved in immune response