SLC16A5

Entrez Summary: N/A
UniProt Summary: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Citral 75μM R06 exp275	-1.96
1-Methyl-nicotinamide-chloride 1000μM R03 exp113	-1.76
UM0011500 10μM R05 exp246	-1.76
Arsenate 40μM R06 exp264	-1.75
Torin1 0.08μM R02 exp82	-1.74

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

monocarboxylic acid transmembrane transporter activity
symporter activity
monocarboxylic acid transport
organic acid transport
carboxylic acid transport
organic anion transport
anion transport
transmembrane transport
ion transport
integral component of plasma membrane
membrane