SLC17A4

Entrez Summary: N/A
UniProt Summary: Acts as a membrane potential-dependent organic anion transporter, the transport requires a low concentration of chloride ions. May be involved in urate extrusion from the intestinal duct. May recognize hydrophilic anionic drugs such as aspirin, salicylate, and ibuprofen as substrates. Able to actively transport inorganic phosphate into cells via Na(+) cotransport (in vitro). {ECO:0000269|PubMed:22460716}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

sialic acid transmembrane transporter activity
sodium:phosphate symporter activity
sialic acid transport
carbohydrate derivative transport
sodium ion transmembrane transport
sodium ion transport
lysosome
organic acid transport
carboxylic acid transport
apical plasma membrane
monovalent inorganic cation transport
organic anion transport
inorganic cation transmembrane transport
anion transport
cation transmembrane transport
metal ion transport
inorganic ion transmembrane transport
cation transport
ion transmembrane transport
transmembrane transport
ion transport
integral component of plasma membrane
membrane