SLC19A1 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC19A1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC19A1
  * **<color #00a2e8>Official Name</color>**: solute carrier family 19 member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6573|6573]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P41440|P41440]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC19A1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC19A1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600424|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The membrane protein encoded by this gene is a transporter of folate and is involved in the regulation of intracellular concentrations of folate. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transporter for the intake of folate. Uptake of folate in human placental choriocarcinoma cells occurs by a novel mechanism called potocytosis which functionally couples three components, namely the folate receptor, the folate transporter, and a V-type H(+)-pump.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Folate carrier|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|folate:anion antiporter activity|
|methotrexate transmembrane transporter activity|
|methotrexate transport|
|folic acid transmembrane transporter activity|
|folate import across plasma membrane|
|folate transmembrane transport|
|folic acid transport|
|folic acid binding|
|vitamin transmembrane transport|
|folic acid metabolic process|
|modified amino acid transport|
|folic acid-containing compound metabolic process|
|pteridine-containing compound metabolic process|
|vitamin transport|
|cofactor transport|
|drug transmembrane transport|
|dicarboxylic acid transport|
|water-soluble vitamin metabolic process|
|dicarboxylic acid metabolic process|
|import across plasma membrane|
|vitamin metabolic process|
|carboxylic acid transmembrane transport|
|organic acid transmembrane transport|
|drug transport|
|basolateral plasma membrane|
|cellular modified amino acid metabolic process|
|coenzyme metabolic process|
|anion transmembrane transport|
|carboxylic acid transport|
|organic acid transport|
|apical plasma membrane|
|cofactor metabolic process|
|organic anion transport|
|drug metabolic process|
|anion transport|
|import into cell|
|cellular amide metabolic process|
|carboxylic acid metabolic process|
|ion transmembrane transport|
|oxoacid metabolic process|
|response to drug|
|organic acid metabolic process|
|transmembrane transport|
|ion transport|
|integral component of plasma membrane|
|amide transport|
|small molecule metabolic process|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-3.66|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|1.71|
|[[:results:exp224|CB-839 10μM R05 exp224]]|1.72|
|[[:results:exp519|RS-1 10μM R08 exp519]]|1.72|
|[[:results:exp534|Trientine 500μM R08 exp534]]|1.74|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|1.75|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|1.76|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.79|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|1.8|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|1.82|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|1.82|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|1.9|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|1.92|
|[[:results:exp360|Genistein 15μM R07 exp360]]|1.98|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|2.01|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|2.01|
|[[:results:exp274|Citral 50μM R06 exp274]]|2.11|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|2.27|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|2.38|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|2.49|
|[[:results:exp116|AICAR 240μM R03 exp116]]|3.85|
|[[:results:exp211|AICAR 240μM R05 exp211]]|5.15|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|8.43|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:naa60|NAA60]]|0.463|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1462
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC19A1 Expression in NALM6 Cells: 6.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>