SLC19A1

Entrez Summary: The membrane protein encoded by this gene is a transporter of folate and is involved in the regulation of intracellular concentrations of folate. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011].
UniProt Summary: Transporter for the intake of folate. Uptake of folate in human placental choriocarcinoma cells occurs by a novel mechanism called potocytosis which functionally couples three components, namely the folate receptor, the folate transporter, and a V-type H(+)-pump.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Trimetrexate 0.03μM R08 exp535	-3.66
QNZ 0.01μM R05 exp241	1.71
CB-839 10μM R05 exp224	1.72
RS-1 10μM R08 exp519	1.72
Trientine 500μM R08 exp534	1.74
CoCl2 18μM R07 exp346	1.75
Clomiphene 4.4μM R02 exp68	1.76
iCRT14 30μM R08 exp492	1.79
Q15 1 to 2μM on day4 R04 exp164	1.8
Cannabidiol 20μM R08 exp466	1.82
Senexin-A 25μM R07 exp400	1.82
INK128 0.2μM R02 exp70	1.9
KU-0063794 3.8μM R02 exp71	1.92
Genistein 15μM R07 exp360	1.98
Hypoxia 5%O2 R04 exp191	2.01
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	2.01
Citral 50μM R06 exp274	2.11
Methotrexate 0.01μM R08 exp501	2.27
IU1-C 25μM R04 exp183	2.38
Arsenic trioxide 60μM R08 exp449	2.49
AICAR 240μM R03 exp116	3.85
AICAR 240μM R05 exp211	5.15
Aminopterin 0.005μM R07 exp335	8.43

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

folate:anion antiporter activity
methotrexate transmembrane transporter activity
methotrexate transport
folic acid transmembrane transporter activity
folate import across plasma membrane
folate transmembrane transport
folic acid transport
folic acid binding
vitamin transmembrane transport
folic acid metabolic process
modified amino acid transport
folic acid-containing compound metabolic process
pteridine-containing compound metabolic process
vitamin transport
cofactor transport
drug transmembrane transport
dicarboxylic acid transport
water-soluble vitamin metabolic process
dicarboxylic acid metabolic process
import across plasma membrane
vitamin metabolic process
carboxylic acid transmembrane transport
organic acid transmembrane transport
drug transport
basolateral plasma membrane
cellular modified amino acid metabolic process
coenzyme metabolic process
anion transmembrane transport
carboxylic acid transport
organic acid transport
apical plasma membrane
cofactor metabolic process
organic anion transport
drug metabolic process
anion transport
import into cell
cellular amide metabolic process
carboxylic acid metabolic process
ion transmembrane transport
oxoacid metabolic process