SLC19A2 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC19A2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC19A2
  * **<color #00a2e8>Official Name</color>**: solute carrier family 19 member 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10560|10560]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60779|O60779]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC19A2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC19A2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603941|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the thiamin transporter protein. Mutations in this gene cause thiamin-responsive megaloblastic anemia syndrome (TRMA), which is an autosomal recessive disorder characterized by diabetes mellitus, megaloblastic anemia and sensorineural deafness. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  High-affinity transporter for the intake of thiamine. {ECO:0000269|PubMed:10391222, ECO:0000269|PubMed:10542220}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Folate carrier|
|MFS 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|thiamine transmembrane transport|
|thiamine transmembrane transporter activity|
|thiamine transport|
|folic acid transmembrane transporter activity|
|thiamine-containing compound metabolic process|
|folic acid transport|
|pyrimidine-containing compound transmembrane transport|
|vitamin transmembrane transport|
|azole transport|
|modified amino acid transport|
|vitamin transport|
|sulfur compound transport|
|cofactor transport|
|drug transmembrane transport|
|dicarboxylic acid transport|
|water-soluble vitamin metabolic process|
|pyrimidine-containing compound metabolic process|
|vitamin metabolic process|
|drug transport|
|carboxylic acid transport|
|organic acid transport|
|sulfur compound metabolic process|
|organic anion transport|
|drug metabolic process|
|anion transport|
|response to drug|
|transmembrane transport|
|ion transport|
|amide transport|
|small molecule metabolic process|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|-2.12|
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|-1.81|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|1.97|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16500
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC19A2 Expression in NALM6 Cells: -6.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>