SLC1A3 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC1A3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC1A3
  * **<color #00a2e8>Official Name</color>**: solute carrier family 1 member 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6507|6507]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P43003|P43003]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC1A3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC1A3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600111|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of a member of a high affinity glutamate transporter family. This gene functions in the termination of excitatory neurotransmission in central nervous system. Mutations are associated with episodic ataxia, Type 6. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7521911, PubMed:8123008, PubMed:20477940, PubMed:26690923, PubMed:28032905, PubMed:28424515). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:20477940). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:20477940). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity). {ECO:0000250|UniProtKB:P56564, ECO:0000269|PubMed:20477940, ECO:0000269|PubMed:26690923, ECO:0000269|PubMed:28032905, ECO:0000269|PubMed:28424515, ECO:0000269|PubMed:7521911, ECO:0000269|PubMed:8123008}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SDF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|L-aspartate import across plasma membrane|
|glutamate:sodium symporter activity|
|gamma-aminobutyric acid biosynthetic process|
|D-aspartate import across plasma membrane|
|D-aspartate transport|
|high-affinity glutamate transmembrane transporter activity|
|gamma-aminobutyric acid metabolic process|
|glutamate biosynthetic process|
|D-amino acid transport|
|L-aspartate transmembrane transport|
|L-glutamate import across plasma membrane|
|L-glutamate import|
|glutamate binding|
|L-glutamate transmembrane transporter activity|
|auditory behavior|
|dicarboxylic acid biosynthetic process|
|mechanosensory behavior|
|amino acid import across plasma membrane|
|L-glutamate transmembrane transport|
|glutamine family amino acid biosynthetic process|
|amino acid import|
|C4-dicarboxylate transport|
|response to auditory stimulus|
|neurotransmitter uptake|
|glutamate secretion|
|glutamate metabolic process|
|neurotransmitter biosynthetic process|
|L-alpha-amino acid transmembrane transport|
|acidic amino acid transport|
|cranial nerve development|
|neuromuscular process controlling balance|
|L-amino acid transport|
|alpha-amino acid biosynthetic process|
|drug transmembrane transport|
|glutamine family amino acid metabolic process|
|amino acid transmembrane transport|
|dicarboxylic acid transport|
|nerve development|
|acid secretion|
|cellular amino acid biosynthetic process|
|chloride transmembrane transport|
|neurotransmitter metabolic process|
|dicarboxylic acid metabolic process|
|import across plasma membrane|
|chloride transport|
|neuromuscular process|
|inorganic anion transmembrane transport|
|amino acid transport|
|carboxylic acid transmembrane transport|
|organic acid transmembrane transport|
|sensory perception of sound|
|drug transport|
|positive regulation of synaptic transmission|
|inorganic anion transport|
|potassium ion transmembrane transport|
|sensory perception of mechanical stimulus|
|potassium ion transport|
|neurotransmitter transport|
|monocarboxylic acid biosynthetic process|
|alpha-amino acid metabolic process|
|response to mechanical stimulus|
|anion transmembrane transport|
|organic acid transport|
|carboxylic acid transport|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|response to antibiotic|
|response to light stimulus|
|cellular amino acid metabolic process|
|neuron projection|
|regulation of neurotransmitter levels|
|neuronal cell body|
|monovalent inorganic cation transport|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|cell morphogenesis involved in neuron differentiation|
|trans-synaptic signaling|
|response to radiation|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|organic anion transport|
|synaptic signaling|
|monocarboxylic acid metabolic process|
|cell morphogenesis involved in differentiation|
|inorganic cation transmembrane transport|
|response to wounding|
|behavior|
|anion transport|
|small molecule biosynthetic process|
|cation transmembrane transport|
|cell surface|
|metal ion transport|
|inorganic ion transmembrane transport|
|import into cell|
|cell morphogenesis|
|neuron development|
|cellular component morphogenesis|
|cation transport|
|carboxylic acid metabolic process|
|ion transmembrane transport|
|sensory perception|
|oxoacid metabolic process|
|secretion by cell|
|neuron differentiation|
|response to drug|
|organic acid metabolic process|
|export from cell|
|cell-cell signaling|
|secretion|
|response to abiotic stimulus|
|transmembrane transport|
|ion transport|
|nervous system process|
|integral component of plasma membrane|
|organonitrogen compound biosynthetic process|
|generation of neurons|
|neurogenesis|
|cell development|
|small molecule metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|nitrogen compound transport|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|-1.91|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|-1.74|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|1.77|
|[[:results:exp131|L-74142 5μM R03 exp131]]|1.94|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7178
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC1A3 Expression in NALM6 Cells: 4.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>