SLC1A3

Entrez Summary: This gene encodes a member of a member of a high affinity glutamate transporter family. This gene functions in the termination of excitatory neurotransmission in central nervous system. Mutations are associated with episodic ataxia, Type 6. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2014].
UniProt Summary: Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7521911, PubMed:8123008, PubMed:20477940, PubMed:26690923, PubMed:28032905, PubMed:28424515). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:20477940). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:20477940). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity). {ECO:0000250|UniProtKB:P56564, ECO:0000269|PubMed:20477940, ECO:0000269|PubMed:26690923, ECO:0000269|PubMed:28032905, ECO:0000269|PubMed:28424515, ECO:0000269|PubMed:7521911, ECO:0000269|PubMed:8123008}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Rotenone 0.07μM R08 exp431	-1.91
Epigallocatechin gallate 20μM R05 exp230	-1.74
BI-2536 0.0042μM R03 exp95	1.77
L-74142 5μM R03 exp131	1.94

L-aspartate import across plasma membrane
glutamate:sodium symporter activity
gamma-aminobutyric acid biosynthetic process
D-aspartate import across plasma membrane
D-aspartate transport
high-affinity glutamate transmembrane transporter activity
gamma-aminobutyric acid metabolic process
glutamate biosynthetic process
D-amino acid transport
L-aspartate transmembrane transport
L-glutamate import across plasma membrane
L-glutamate import
glutamate binding
L-glutamate transmembrane transporter activity
auditory behavior
dicarboxylic acid biosynthetic process
mechanosensory behavior
amino acid import across plasma membrane
L-glutamate transmembrane transport
glutamine family amino acid biosynthetic process
amino acid import
C4-dicarboxylate transport
response to auditory stimulus
neurotransmitter uptake
glutamate secretion
glutamate metabolic process
neurotransmitter biosynthetic process
L-alpha-amino acid transmembrane transport
acidic amino acid transport
cranial nerve development
neuromuscular process controlling balance
L-amino acid transport
alpha-amino acid biosynthetic process
drug transmembrane transport
glutamine family amino acid metabolic process
amino acid transmembrane transport
dicarboxylic acid transport
nerve development
acid secretion
cellular amino acid biosynthetic process