SLC1A4 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC1A4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC1A4
  * **<color #00a2e8>Official Name</color>**: solute carrier family 1 member 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6509|6509]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P43007|P43007]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC1A4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC1A4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600229|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a sodium-dependent neutral amino acid transporter for alanine, serine, cysteine, and threonine. Defects in this gene have been associated with developmental delay, microcephaly, and intellectual disability. [provided by RefSeq, Jan 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transporter for alanine, serine, cysteine, and threonine. Exhibits sodium dependence. {ECO:0000269|PubMed:26041762}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SDF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|L-hydroxyproline transmembrane transporter activity|
|threonine transport|
|hydroxyproline transport|
|L-threonine transmembrane transporter activity|
|L-cystine transport|
|L-cystine transmembrane transporter activity|
|L-glutamine transmembrane transporter activity|
|L-serine transport|
|L-serine transmembrane transporter activity|
|glutamine transport|
|L-proline transmembrane transporter activity|
|proline transmembrane transport|
|L-alanine transmembrane transporter activity|
|serine transport|
|L-alanine transport|
|sulfur amino acid transport|
|proline transport|
|alanine transport|
|modified amino acid transport|
|synaptic transmission, glutamatergic|
|neutral amino acid transport|
|amino acid transmembrane transporter activity|
|symporter activity|
|sulfur compound transport|
|chloride channel activity|
|L-amino acid transport|
|amino acid transmembrane transport|
|chloride transmembrane transport|
|melanosome|
|chloride transport|
|inorganic anion transmembrane transport|
|intermediate filament|
|amino acid transport|
|organic acid transmembrane transport|
|carboxylic acid transmembrane transport|
|microtubule organizing center|
|inorganic anion transport|
|anion transmembrane transport|
|carboxylic acid transport|
|organic acid transport|
|cognition|
|neuronal cell body|
|anterograde trans-synaptic signaling|
|dendrite|
|chemical synaptic transmission|
|trans-synaptic signaling|
|organic anion transport|
|synaptic signaling|
|centrosome|
|anion transport|
|cation transmembrane transport|
|cell surface|
|inorganic ion transmembrane transport|
|cation transport|
|ion transmembrane transport|
|cell-cell signaling|
|transmembrane transport|
|ion transport|
|nervous system process|
|integral component of plasma membrane|
|nitrogen compound transport|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|-1.71|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|1.73|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|1.77|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12039
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC1A4 Expression in NALM6 Cells: 6.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>