SLC1A4

Entrez Summary: The protein encoded by this gene is a sodium-dependent neutral amino acid transporter for alanine, serine, cysteine, and threonine. Defects in this gene have been associated with developmental delay, microcephaly, and intellectual disability. [provided by RefSeq, Jan 2017].
UniProt Summary: Transporter for alanine, serine, cysteine, and threonine. Exhibits sodium dependence. {ECO:0000269|PubMed:26041762}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

L-hydroxyproline transmembrane transporter activity
threonine transport
hydroxyproline transport
L-threonine transmembrane transporter activity
L-cystine transport
L-cystine transmembrane transporter activity
L-glutamine transmembrane transporter activity
L-serine transport
L-serine transmembrane transporter activity
glutamine transport
L-proline transmembrane transporter activity
proline transmembrane transport
L-alanine transmembrane transporter activity
serine transport
L-alanine transport
sulfur amino acid transport
proline transport
alanine transport
modified amino acid transport
synaptic transmission, glutamatergic
neutral amino acid transport
amino acid transmembrane transporter activity
symporter activity
sulfur compound transport
chloride channel activity
L-amino acid transport
amino acid transmembrane transport
chloride transmembrane transport
melanosome
chloride transport
inorganic anion transmembrane transport
intermediate filament
amino acid transport
organic acid transmembrane transport
carboxylic acid transmembrane transport
microtubule organizing center
inorganic anion transport
anion transmembrane transport
carboxylic acid transport
organic acid transport