SLC22A4 [The Human Chemical-Genetic Interaction Map Project]

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======= SLC22A4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC22A4
  * **<color #00a2e8>Official Name</color>**: solute carrier family 22 member 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6583|6583]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H015|Q9H015]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC22A4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC22A4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604190|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is an organic cation transporter and plasma integral membrane protein containing eleven putative transmembrane domains as well as a nucleotide-binding site motif. Transport by this protein is at least partially ATP-dependent. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Sodium-ion dependent, low affinity carnitine transporter. Probably transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 1.78. A key substrate of this transporter seems to be ergothioneine (ET). {ECO:0000269|PubMed:10215651, ECO:0000269|PubMed:15795384}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MFS 1|
|Sugar tr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cation:cation antiporter activity|
|secondary active organic cation transmembrane transporter activity|
|carnitine transmembrane transport|
|carnitine transmembrane transporter activity|
|quaternary ammonium group transmembrane transporter activity|
|carnitine transport|
|amino-acid betaine transport|
|quaternary ammonium group transport|
|carnitine metabolic process|
|ammonium transmembrane transport|
|amino-acid betaine metabolic process|
|modified amino acid transport|
|organic cation transport|
|symporter activity|
|ammonium transport|
|nucleotide binding|
|body fluid secretion|
|triglyceride metabolic process|
|PDZ domain binding|
|acylglycerol metabolic process|
|neutral lipid metabolic process|
|sodium ion transport|
|ammonium ion metabolic process|
|cellular modified amino acid metabolic process|
|apical plasma membrane|
|glycerolipid metabolic process|
|monovalent inorganic cation transport|
|regulation of body fluid levels|
|cation transmembrane transport|
|metal ion transport|
|cation transport|
|ion transmembrane transport|
|cellular lipid metabolic process|
|secretion|
|lipid metabolic process|
|mitochondrion|
|transmembrane transport|
|ion transport|
|integral component of plasma membrane|
|ATP binding|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-2.48|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-1.77|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|-1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8496
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.82 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC22A4 Expression in NALM6 Cells: -1.82'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>