SLC22A4
Gene Information
- Official Symbol: SLC22A4
- Official Name: solute carrier family 22 member 4
- Aliases and Previous Symbols: N/A
- Entrez ID: 6583
- UniProt: Q9H015
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is an organic cation transporter and plasma integral membrane protein containing eleven putative transmembrane domains as well as a nucleotide-binding site motif. Transport by this protein is at least partially ATP-dependent. [provided by RefSeq, Jul 2008].
- UniProt Summary: Sodium-ion dependent, low affinity carnitine transporter. Probably transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 1.78. A key substrate of this transporter seems to be ergothioneine (ET). {ECO:0000269|PubMed:10215651, ECO:0000269|PubMed:15795384}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 8496
- Expression level (log2 read counts): -1.82
SLC22A4 Expression in NALM6 Cells: -1.82
