SLC23A1

Entrez Summary: N/A
UniProt Summary: Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Metformin 100 to 150μM on day4 R04 exp170	1.71
Geldanamycin 0.01μM R05 exp235	1.89

L-ascorbic acid transmembrane transport
L-ascorbate:sodium symporter activity
L-ascorbic acid transmembrane transporter activity
transepithelial L-ascorbic acid transport
sodium-dependent L-ascorbate transmembrane transporter activity
nucleobase transmembrane transporter activity
intracellular organelle
dehydroascorbic acid transmembrane transporter activity
sodium ion transmembrane transporter activity
dehydroascorbic acid transport
coenzyme transport
nucleobase transport
L-ascorbic acid metabolic process
vitamin transmembrane transport
transepithelial transport
basal plasma membrane
monosaccharide transmembrane transport
carbohydrate transmembrane transport
vitamin transport
transporter activity
cofactor transport
carbohydrate transport
water-soluble vitamin metabolic process
sodium ion transmembrane transport
vitamin metabolic process
organic acid transmembrane transport
carboxylic acid transmembrane transport
sodium ion transport
lung development
respiratory tube development
respiratory system development
monosaccharide metabolic process
coenzyme metabolic process
anion transmembrane transport
carboxylic acid transport
organic acid transport
apical plasma membrane
monovalent inorganic cation transport
cofactor metabolic process
organic anion transport